Nausea and vomiting of pregnancy:: what about quality of life?

Objective The objective of this study was to determine the impact of nausea and vomiting of pregnancy (NVP) and other determinants on generic and NVP-specific health-related quality of life (QOL) in the first trimester of pregnancy. Design Prospective study. Setting Centre Hospitalier Universitaire (CHU) Sainte-Justine or Rene-Laennec clinics, Montreal, Quebec, Canada. Population Pregnant women attending the clinics for their prenatal care from 2004 to 2006. Women were eligible if they were >= 18 years of age and <= 16 weeks of gestation at the time of their first prenatal visit. Methods After their first prenatal visit, women were asked to fill out a questionnaire covering maternal characteristics, presence and severity of NVP, and health-related QOL. Main outcome measures QOL was measured by the generic 12-item Short Form Health Survey v. 1 (SF-12) and the NVP-specific Quality of Life for Nausea and Vomiting during Pregnancy. Results Of the 367 pregnant women included in the study, 78.5% of women reported NVP in the first trimester of pregnancy. Multivariable linear models showed that presence of NVP in the first trimester of pregnancy was significantly associated with a lower physical component summary scale (P < 0.0001) and mental component summary scale (P = 0.0066) of the SF-12 scores. More severe NVP (moderate versus mild: P = 0.0002; severe versus mild: P = 0.0177 as measured by the validated modified Pregnancy-Unique Quantification of Emesis and Nausea index), intensity of nausea symptoms reported on a visual analogue scale (P < 0.0001), and nonpharmacological methods used to ease NVP symptoms in the first trimester of pregnancy (P = 0.0059) were significantly associated with poorer NVP-specific QOL among women suffering from NVP. Conclusion These findings show that presence and severity of NVP have a negative impact on health-related QOL, which emphasises the importance of an optimal management of NVP.