Control-oriented physiological modeling of hemodynamic responses to blood volume perturbation

被引：29

作者：

Bighamian, Ramin ^{[1
]}

Parvinian, Bahram ^{[2
]}

Scully, Christopher G. ^{[2
]}

Kramer, George ^{[3
]}

Hahn, Jin-Oh ^{[4
]}

机构：

[1] Univ Southern Calif, Dept Elect Engn, Los Angeles, CA 90089 USA

[2] US FDA, Off Sci & Engn Labs, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA

[3] Univ Texas Med Branch, Dept Anesthesiol, Galveston, TX 77555 USA

[4] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA

来源：

CONTROL ENGINEERING PRACTICE | 2018年 / 73卷

关键词：

Mathematical model; Hemodynamic response; Fluid infusion; Hemorrhage; Fluid resuscitation; Blood volume; Physiological closed-loop control; CLOSED-LOOP RESUSCITATION; FLUID RESUSCITATION; MULTIPLE HEMORRHAGES; ARTERIAL-PRESSURE; COMPUTER-MODEL; MANAGEMENT; BAROREFLEX; OPTIMIZATION; RESTITUTION; SIMULATION;

D O I：

10.1016/j.conengprac.2018.01.008

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：149 / 160

页数：12

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