Targeted Drug Therapy to Overcome Chemoresistance in Triple-negative Breast Cancer

被引:23
作者
Kumari, Mamta [1 ]
Krishnamurthy, Praveen Thaggikuppe [1 ]
Sola, Piyong [1 ]
机构
[1] JSS Coll Pharm, Dept Pharmacol, Ooty, Tamil Nadu, India
关键词
Triple-negative breast cancer; metastasis; chemoresistance; nanocarriers; drug therapy; GROWTH-FACTOR RECEPTOR; STEM-CELLS; ALDEHYDE DEHYDROGENASE; MULTIDRUG-RESISTANCE; CARBON NANOTUBES; P-GLYCOPROTEIN; MONOCLONAL-ANTIBODY; COMBINATION THERAPY; DELIVERY-SYSTEMS; SELF-RENEWAL;
D O I
10.2174/1568009620666200506110850
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Triple-negative Breast Cancer (TNBC) is the most aggressive and prevailing breast cancer subtype. The chemotherapeutics used in the treatment of TNBC stiffer from chemoresistance, dose-limiting toxicitics and off-target side effects. As a result, conventional chemotherapeutics are unable to prevent tumor growth, metastasis and result in failure of therapy. Various new targets such as BCSCs surface markers (CD44, CD133, ALDH1), signaling pathways (IL-6/JAK/STAT3, notch), pro and anti-apoptotic proteins (Bcl-2, Bcl-xL, DR4, DR5), hypoxic factors (HIF-1 alpha, HIF-2 alpha) and drug efflux transporters (ABCC1, ABCG2 and ABCB1) have been exploited to treat TNBC. Further, to improve the efficacy and safety of conventional chemotherapeutics, researchers have tried to deliver anticancer agents specifically to the TNBCs using nanocarrier based drug delivery. In this re- view, an effort has been made to highlight the various factors responsible for the chemoresistance in TNBC, novel molecular targets of TNBC and nano-delivery systems employed to achieve site-specific drug delivery to improve efficacy and reduce off-target side effects.
引用
收藏
页码:559 / 572
页数:14
相关论文
共 174 条
[61]   Caspase-3-mediated cleavage of the NF-κB subunit p65 at the NH2 terminus potentiates naphthoquinone analog-induced apoptosis [J].
Kang, KH ;
Lee, KH ;
Kim, MY ;
Choi, KH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) :24638-24644
[62]   Mesenchymal stem cells within tumour stroma promote breast cancer metastasis [J].
Karnoub, Antoine E. ;
Dash, Ajeeta B. ;
Vo, Annie P. ;
Sullivan, Andrew ;
Brooks, Mary W. ;
Bell, George W. ;
Richardson, Andrea L. ;
Polyak, Kornelia ;
Tubo, Ross ;
Weinberg, Robert A. .
NATURE, 2007, 449 (7162) :557-U4
[63]   PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges [J].
Khan, Mohammad A. ;
Jain, Vineet K. ;
Rizwanullah, Md. ;
Ahmad, Javed ;
Jain, Keerti .
DRUG DISCOVERY TODAY, 2019, 24 (11) :2181-2191
[64]   An Allelic Series of Mice Reveals a Role for RERE in the Development of Multiple Organs Affected in Chromosome 1p36 Deletions [J].
Kim, Bum Jun ;
Zaveri, Hitisha P. ;
Shchelochkov, Oleg A. ;
Yu, Zhiyin ;
Hernandez-Garcia, Andres ;
Seymour, Michelle L. ;
Oghalai, John S. ;
Pereira, Fred A. ;
Stockton, David W. ;
Justice, Monica J. ;
Lee, Brendan ;
Scott, Daryl A. .
PLOS ONE, 2013, 8 (02)
[65]   Different prognostic significance of CD24 and CD44 expression in breast cancer according to hormone receptor status [J].
Kim, Hee Jeong ;
Kim, Mi-Jung ;
Ahn, Sei Hyun ;
Son, Byung Ho ;
Kim, Sung Bae ;
Ahn, Jin Hee ;
Noh, Woo Chul ;
Gong, Gyungyub .
BREAST, 2011, 20 (01) :78-85
[66]   Combination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer [J].
Kim, Hyunki ;
Samuel, Sharon L. ;
Zhai, Guihua ;
Rana, Samir ;
Taylor, Marie ;
Umphrey, Heidi R. ;
Oelschlager, Denise K. ;
Buchsbaum, Donald J. ;
Zinn, Kurt R. .
CANCER BIOLOGY & THERAPY, 2014, 15 (08) :1053-1060
[67]   Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells [J].
Kim, Seog-Young ;
Kang, Jin Wook ;
Song, Xinxin ;
Kim, Bo Kyoung ;
Yoo, Young Dong ;
Kwon, Yong Tae ;
Lee, Yong J. .
CELLULAR SIGNALLING, 2013, 25 (04) :961-969
[68]   Myeloperoxidase: a front-line defender against phagocytosed microorganisms [J].
Klebanoff, Seymour J. ;
Kettle, Anthony J. ;
Rosen, Henry ;
Winterbourn, Christine C. ;
Nauseef, William M. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2013, 93 (02) :185-198
[69]   γ-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers [J].
Konishi, Jun ;
Kawaguchi, Keiko S. ;
Vo, Huan ;
Haruki, Nobuhiro ;
Gonzalez, Adriana ;
Carbone, David P. ;
Dang, Thao P. .
CANCER RESEARCH, 2007, 67 (17) :8051-8057
[70]   P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 Determine the Pharmacokinetics of Etoposide [J].
Lagas, Jurjen S. ;
Fan, Lin ;
Wagenaar, Els ;
Vlaming, Maria L. H. ;
van Tellingen, Olaf ;
Beijnen, Jos H. ;
Schinkel, Alfred H. .
CLINICAL CANCER RESEARCH, 2010, 16 (01) :130-140