Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing

被引:281
作者
Butler, Stephen J. [1 ]
Parker, David [1 ]
机构
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
关键词
CEREBROSPINAL-FLUID; EUROPIUM LUMINESCENCE; AQUEOUS-SOLUTION; INORGANIC-PHOSPHATE; RATIOMETRIC PROBES; CRYSTAL-STRUCTURES; TERBIUM COMPLEXES; DIAQUA-YTTERBIUM; TERNARY ADDUCTS; AMINO-ACIDS;
D O I
10.1039/c2cs35144g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Reversible anion binding at lanthanide centres in aqueous media has emerged as an effective means of signalling and sensing the presence of selected anions. The constitution and configuration of a wide range of anion adducts has been defined by X-ray analyses and NMR methods, and both chelating and monodentate binding modes characterised. Variation of the lanthanide ion modulates charge density, and ligand modification allows alteration of both the peripheral electrostatic gradient and the local steric demand at the metal centre. Thus, selectivity for a target anion can be engineered, and the affinity constant modulated to target the desired concentration range. Changes in anion concentration can be monitored rapidly, accurately and with high spatial resolution using optical emission spectroscopy and microscopy, facilitating the measurement of anions such as bicarbonate, lactate, citrate and urate in a variety of bio-fluids.
引用
收藏
页码:1652 / 1666
页数:15
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