HIV, Depression, and Cognitive Impairment in the Era of Effective Antiretroviral Therapy

被引：128

作者：

Rubin, Leah H. ^{[1
,2
]}

Maki, Pauline M. ^{[3
,4
]}

机构：

[1] Johns Hopkins Sch Med, Dept Neurol, 600 N Wolfe St,Meyer 6-133a, Baltimore, MD 21287 USA

[2] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[3] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[4] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA

来源：

CURRENT HIV/AIDS REPORTS | 2019年 / 16卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HIV; Depression; Depressive symptoms; Cognitive impairment; HAND; QUALITY-OF-LIFE; TARGETING MAJOR DEPRESSION; NEUROCOGNITIVE IMPAIRMENT; BEHAVIORAL THERAPY; INFECTED INDIVIDUALS; PROSPECTIVE MEMORY; PSYCHIATRIC-DISORDERS; POSTTRAUMATIC-STRESS; UNIPOLAR DEPRESSION; PREFRONTAL CORTEX;

D O I：

10.1007/s11904-019-00421-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of ReviewMental health disorders, especially depression, are prevalent among people living with HIV (PLWH) and are associated with cognitive impairment (CI) among HIV-uninfected (HIV-) individuals. We conducted a comprehensive review of the link between depression and cognition among PLWH.Recent FindingsStudies examining depression and cognition in PLWH report high rates of current (median=24%) and lifetime depression (42%). There is reliable evidence that depression is associated with overall CI among PLWH, and in the cognitive domains of processing speed, executive function, learning and memory, and motor function. Although few studies have examined the interaction between HIV serostatus and depression on CI, there is no evidence of a stronger association between CI and depression in PLWH compared with HIV- controls.SummaryDepression is prevalent and reliably associated with CI in PLWH, with an overall pattern of domain-specific associations similar to that of HIV- individuals.

引用

页码：82 / 95

页数：14

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