Synthesis of γ,δ-unsaturated-β-keto lactones via sequential cross metathesis-lactonization:: A facile entry to macrolide antibiotic (-)-A26771B

被引：34

作者：

Gebauer, J ^{[1
]}

Blechert, S ^{[1
]}

机构：

[1] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 05期

关键词：

D O I：

10.1021/jo052421a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple access to gamma,delta-unsaturated-beta-keto lactones is presented, allowing a rapid total synthesis of the naturally occurring 16-membered macrolide antibiotic (-)-A26771B via cross metathesis, asymmetric dihydroxylation, and lactonization as the key steps.

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页码：2021 / 2025

页数：5

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