RETRACTED: Sirtuin-3 modulates Bak- and Bax-dependent apoptosis (Publication with Expression of Concern. See vol. 129, pg. 871, 2016) (Publication with Expression of Concern. See vol. 129, pg. 871, 2016) (Retracted article. See vol. 129, pg. 2687, 2016)

Sirtuin-3 exhibits properties of a tumor suppressor partly emanating from its ability to control the state of mitochondrial metabolism, with depletion of sirt-3 increasing tumor cell survival. In the present study we demonstrate that depletion of sirtuin-3 brings about an anti-apoptotic phenotype via stimulating cyclophilin-D activity, which promotes the binding of hexokinase II to the mitochondria, thereby preventing Bak/Bax dependent mitochondrial injury and cell death. By contrast, increased expression of sirtuin-3 decreases cyclophilin-D activity, resulting in detachment of hexokinase II from the mitochondria and potentiation of Bak- and Bax-induced mitochondrial injury and loss of cell viability.