RETRACTED: Sirtuin-3 modulates Bak- and Bax-dependent apoptosis (Publication with Expression of Concern. See vol. 129, pg. 871, 2016) (Publication with Expression of Concern. See vol. 129, pg. 871, 2016) (Retracted article. See vol. 129, pg. 2687, 2016)

被引：20

作者：

Verma, Manish ^{[1
]}

Shulga, Nataly ^{[1
]}

Pastorino, John G. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Sch Osteopath Med, Dept Mol Biol, Stratford, NJ 08084 USA

来源：

JOURNAL OF CELL SCIENCE | 2013年 / 126卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Sirtuin-3; Mitochondria; Hexokinase-2; Bak; Bax; Apoptosis; Cisplatin; MITOCHONDRIAL PERMEABILITY TRANSITION; PROGRAMMED CELL-DEATH; CYCLOPHILIN-D; HEXOKINASE-II; TUMOR-SUPPRESSOR; ANION CHANNEL; CANCER-CELLS; SIRT3; HYPOXIA; DEACETYLATION;

D O I：

10.1242/jcs.115188

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sirtuin-3 exhibits properties of a tumor suppressor partly emanating from its ability to control the state of mitochondrial metabolism, with depletion of sirt-3 increasing tumor cell survival. In the present study we demonstrate that depletion of sirtuin-3 brings about an anti-apoptotic phenotype via stimulating cyclophilin-D activity, which promotes the binding of hexokinase II to the mitochondria, thereby preventing Bak/Bax dependent mitochondrial injury and cell death. By contrast, increased expression of sirtuin-3 decreases cyclophilin-D activity, resulting in detachment of hexokinase II from the mitochondria and potentiation of Bak- and Bax-induced mitochondrial injury and loss of cell viability.

引用

页码：274 / 288

页数：15