Hepatic metastases: In vivo assessment of perfusion parameters at dynamic contrast-enhanced MR Imaging with dual-input two-compartment tracer kinetics model

被引:85
作者
Koh, Tong San [2 ]
Thng, Choon Hua [3 ]
Lee, Puor Sherng [3 ]
Hartono, Septian [2 ,3 ]
Rumpel, Helmut [4 ]
Goh, Boon Cher [5 ]
Bisdas, Sotirios [1 ]
机构
[1] Johann Wolfgang Goethe Univ Hosp, Dept Radiol, D-60590 Frankfurt, Germany
[2] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore, Singapore
[3] Natl Canc Ctr, Dept Oncol Imaging, Singapore, Singapore
[4] Singapore Gen Hosp, Dept Diagnost Radiol, Singapore 0316, Singapore
[5] Natl Univ Singapore, Natl Univ Hosp, Singapore 117548, Singapore
关键词
D O I
10.1148/radiol.2483071958
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This study was institutional review board approved, with waived patient consent for retrospective analysis of the data. The hepatic perfusion at dynamic contrast material enhanced magnetic resonance (MR) imaging was commonly described and assessed by using a dual-input one-compartment tracer kinetics model. Although the tracer kinetics in normal liver parenchyma can be described by using a single compartment, functional changes in the tumor microenvironment can result in distinctly different tracer behavior that entails a second tissue compartment. A dual-input two-compartment model is proposed to describe the tracer behavior in hepatic metastases. The authors applied this model to the dynamic MR imaging data obtained in three patients. Perfusion parameter maps and region-of-interest analysis revealed that tracer behavior in hepatic metastases-in contrast to that in surrounding normal liver tissue, which effectively involves one compartment-can be described by using two compartments. (c) RSNA, 2008.
引用
收藏
页码:307 / 320
页数:14
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