Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China

被引：19

作者：

Liu, Mengfei ^{[1
]}

He, Zhonghu ^{[1
]}

Zhang, Chanyuan ^{[1
]}

Liu, Fangfang ^{[1
]}

Liu, Ying ^{[1
]}

Li, Jingjing ^{[1
]}

Xu, Zhongyao ^{[1
]}

Wang, Qiyan ^{[1
]}

Hang, Dong ^{[1
]}

Shen, Na ^{[1
]}

Pan, Yaqi ^{[1
]}

Guo, Chuanhai ^{[1
]}

Cai, Hong ^{[1
]}

Ke, Yang ^{[1
]}

机构：

[1] Peking Univ, Key Lab Carcinogenesis & Translat Res, Genet Lab, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

VIRAL LOAD; CERVICAL-CANCER; DNA; CONCORDANCE; CARCINOMA; BEHAVIOR; WOMEN; MEN;

D O I：

10.1038/srep10986

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

HPV transmission dynamics have rarely been studied in the general population, especially in China. We followed the genital HPV infection status of both partners in 874 couples aged 25-65 years from rural China for up to 7 bi-annual visits during 2009-2013. The positive HPV concordance and transmission rate for partners in a couple were evaluated and relevant risk factors were assessed. The concordance of any, oncogenic, and non-oncogenic HPV was 15.52%, 16.18% and 10.41%, respectively. Male-to-female transmission rate was 7.11, 12.13 and 4.77/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The female-to-male transmission rate was 5.56, 2.37, and 17.01/1000 person months for any, oncogenic and non-oncogenic HPV respectively. The risk of male-to-female transmission was significantly higher than that of female-to-male transmission for oncogenic types. However, for non-oncogenic types, the risk of male-to-female transmission was significantly lower than that of female-to-male transmission. Younger couples, persistent infection with HPV, higher numbers of sexual partners and higher frequency of sexual intercourse were positively associated with HPV transmission in couples. Our results indicate that men in rural China play a more important role than men in western populations as a source of cervical oncogenic HPV infection in women.

引用

页数：10

共 33 条

[1]

AGARWAL SS, 1993, CANCER, V72, P1666, DOI 10.1002/1097-0142(19930901)72:5<1666::AID-CNCR2820720528>3.0.CO

[2]

2-M

[3] Concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads [J].