To differentiate or not - routes towards metastasis

被引：503

作者：

Brabletz, Thomas ^{[1
,2
]}

机构：

[1] Univ Freiburg, Med Ctr, Dept Gen & Visceral Surg, D-79106 Freiburg, Germany

[2] Univ Freiburg, Med Ctr, Ctr Comprehens Canc, D-79106 Freiburg, Germany

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 06期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; CANCER STEM-CELLS; CIRCULATING TUMOR-CELLS; SMALL-MOLECULE INHIBITOR; BREAST-CANCER; E-CADHERIN; MIR-200; FAMILY; BETA-CATENIN; BONE-MARROW; DOWN-REGULATION;

D O I：

10.1038/nrc3265

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Why are many metastases differentiated? Invading and disseminating carcinoma cells can undergo an epithelial-mesenchymal transition (EMT), which is associated with a gain of stem cell-like behaviour. Therefore, EMT has been linked to the cancer stem cell concept. However, it is a matter of debate how subsequent mesenchymal-epithelial transition (MET) fits into the metastatic process and whether a MET is essential. In this Opinion article, I propose two principle types of metastatic progression: phenotypic plasticity involving transient EMT-MET processes and intrinsic genetic alterations keeping cells in an EMT and stemness state. This simplified classification integrates clinically relevant aspects of dormancy, metastatic tropism and therapy resistance, and implies perspectives on treatment strategies against metastasis.

引用

页码：425 / 436

页数：12

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