Effects of insulin on placental, fetal and maternal outcomes in gestational diabetes mellitus

被引：1
作者：
Arshad, Rabia [1 ]
Karim, Nasim [1 ]
Hasa, Jahan Ara [2 ]
机构：
[1] Bahria Univ, Med & Dent Coll, Dept Pharmacol, Karachi, Pakistan
[2] Dow Univ Hlth Sci, Dept Obstet & Gynecol, Karachi, Pakistan
来源：
PAKISTAN JOURNAL OF MEDICAL SCIENCES | 2014年 / 30卷 / 02期
关键词：
Gestational diabetes; Insulin; Placenta; Gross morphology; Fetal outcome; Maternal outcome; PREGNANCIES; MANAGEMENT; DELIVERY; WOMEN;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To observe the effects of exogenous insulin on placental, fetal and maternal outcomes in Gestational Diabetes Mellitus (GPM). Methods: After screening and diagnoses(WHO criteria) 30 GDM patients(Group A) were kept on diet control and 39 GDM (Group B) who did not achieve glycemic targets were added subcutaneous insulin. Term placental weight, size, shape, consistency, fibrinoid necrosis, hemorrhages, cord color, length of the cord, completeness of membranes, weight and condition of baby and mode of delivery were assessed in 25 patients in each group. Result: Placental weight, cord width and baby weight were found to be more in Group B, than Group A and were statistically significant with p value 0.005, 0.02 and 0.003 respectively. Ten patients in group A and 17 patients in group B had cesarean deliveries. Conclusion: Exogenous insulin produces significant effects on the placental, fetal and maternal outcomes in patients with GDM
引用
收藏
页码：240 / 244
页数：5
相关论文
共 50 条
[31]   Maternal and Neonatal Outcomes in Patients of Gestational Diabetes Mellitus on Metformin Therapy [J].
Gupta, Shubhi ;
Takkar, Navneet ;
Goel, Poonam .
JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA, 2019, 69 (06) :490-494
[32]   Updates in Long-term Maternal and Fetal Adverse Effects of Gestational Diabetes Mellitus [J].
Shou, Chong ;
Wei, Yu-Mei ;
Wang, Chen ;
Yang, Hui-Xia .
MATERNAL-FETAL MEDICINE, 2019, 1 (02) :91-94
[33]   Gestational diabetes mellitus induces placental vasculopathies [J].
Aldahmash, Waleed M. ;
Alwasel, Saleh H. ;
Aljerian, Khaldoon .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2022, 29 (13) :19860-19868
[34]   Fetal and Placental Weight in Pre-Gestational Maternal Obesity (PGMO) vs. Excessive Gestational Weight Gain (EGWG)-A Preliminary Approach to the Perinatal Outcomes in Diet-Controlled Gestational Diabetes Mellitus [J].
Gujski, Mariusz ;
Szukiewicz, Dariusz ;
Choluj, Marta ;
Sawicki, Wlodzimierz ;
Bojar, Iwona .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (11)
[35]   The role of obesity and gestational diabetes on placental size and fetal oxygenation [J].
Bianchi, Chiara ;
Taricco, Emanuela ;
Cardellicchio, Manuela ;
Mando, Chiara ;
Massari, Maddalena ;
Savasi, Valeria ;
Cetin, Irene .
PLACENTA, 2021, 103 :59-63
[36]   The Impact of Maternal Gestational Diabetes Mellitus on Minipuberty in Boys [J].
Kowalcze, Karolina ;
Burgio, Sofia ;
Ott, Johannes ;
Gullo, Giuseppe ;
Zaami, Simona ;
Krysiak, Robert .
NUTRIENTS, 2024, 16 (23)
[37]   Maternal plasma adipokines and insulin concentrations in relation to fetal biometry in the gestational diabetes [J].
Bomba-Opon, Dorota A. ;
Horosz, Edyta ;
Szymanska, Monika ;
Wielgos, Miroslaw .
NEUROENDOCRINOLOGY LETTERS, 2010, 31 (04) :568-572
[38]   Metformin versus insulin for gestational diabetes mellitus: a meta-analysis [J].
Zhao, Li-Ping ;
Sheng, Xiao-Yan ;
Zhou, Shuang ;
Yang, Ting ;
Ma, Ling-Yue ;
Zhou, Ying ;
Cui, Yi-Min .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 80 (05) :1224-1234
[39]   Comparison of maternal and fetal outcomes in women with gestational diabetes treated with metformin versus insulin: an open- label randomized clinical trial [J].
Afrakhteh, Maryam ;
Pooransari, Parichehr ;
Niroomand, Mahtab ;
Hosseiniara, Reza ;
Noorollahi, Golshan .
NURSING AND MIDWIFERY STUDIES, 2024, 13 (03) :148-155
[40]   Ramadan and gestational diabetes: maternal and neonatal outcomes [J].
AlMogbel, Turki Abdullah ;
Ross, Glynis ;
Wu, Ted ;
Molyneaux, Lynda ;
Constantino, Maria Ines ;
McGill, Margaret ;
Harding, Anna Jane ;
Pech, Christine ;
Alrasheed, Abdullah A. ;
Wong, Jencia .
ACTA DIABETOLOGICA, 2022, 59 (01) :21-30
12345