GABAergic dysfunction in pediatric neuro-developmental disorders

被引：20

作者：

Smith-Hicks, Constance L. ^{[1
,2
]}

机构：

[1] Kennedy Krieger Inst, Baltimore, MD 21205 USA

[2] Johns Hopkins Sch Med, Baltimore, MD USA

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2013年 / 7卷

关键词：

PV interneurons; synaptic plasticity; critical period; disease; circuits; TS65DN MOUSE MODEL; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; NEUROTROPHIC FACTOR; RAT HIPPOCAMPUS; CRITICAL PERIOD; SYNAPTIC PLASTICITY; BDNF TRANSCRIPTION; AUTISTIC DISORDER; GABA(A) RECEPTORS;

D O I：

10.3389/fncel.2013.00269

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

引用

页数：7

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