Cutting Edge: Antigen Presentation to CD8 T Cells after influenza A Virus Infection

被引：25

作者：

Ingulli, Elizabeth ^{[1
]}

Funatake, Castle ^{[2
,3
]}

Jacovetty, Erica L. ^{[1
]}

Zanetti, Maurizio ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Immunol Lab, Dept Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CD8-ALPHA(+) DENDRITIC CELLS; LYMPH-NODES; LUNG; MIGRATION; IMMUNITY; MICE; DIFFERENTIATION; POPULATIONS; ACTIVATION; NAIVE;

D O I：

10.4049/jimmunol.182.1.29

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, presentation was found to be mediated by a CD11b(+) DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection. The Journal of Immunology, 2009, 182: 29-33.

引用

页码：29 / 33

页数：5

共 22 条

[11] VIRUS-SPECIFIC ANTIGEN PRESENTATION BY DIFFERENT SUBSETS OF CELLS FROM LUNG AND MEDIASTINAL LYMPH-NODE TISSUES OF INFLUENZA VIRUS-INFECTED MICE [J].

HAMILTONEASTON, A ;

EICHELBERGER, M .

JOURNAL OF VIROLOGY, 1995, 69 (10) :6359-6366

[12] In vivo detection of dendritic cell antigen presentation to CD4(+) T cells [J].

Ingulli, E ;

Mondino, A ;

Khoruts, A ;

Jenkins, MK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (12) :2133-2141

[13] Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity [J].

Itano, AA ;

McSorley, SJ ;

Reinhardt, RL ;

Ehst, BD ;

Ingulli, E ;

Rudensky, AY ;

Jenkins, MK .

IMMUNITY, 2003, 19 (01) :47-57

[14] Addition of a prominent epitope affects influenza a virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting [J].

Jenkins, Misty Rayna ;

Webby, Richard ;

Doherty, Peter C. ;

Turner, Stephen J. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (05) :2917-2925

[15] Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells [J].

Junt, Tobias ;

Moseman, E. Ashley ;

Iannacone, Matteo ;

Massberg, Steffen ;

Lang, Philipp A. ;

Boes, Marianne ;

Fink, Katja ;

Henrickson, Sarah E. ;

Shayakhmetov, Dmitry M. ;

Di Paolo, Nelson C. ;

Van Rooijen, Nico ;

Mempel, Thorsten R. ;

Whelan, Sean P. ;

von Andrian, Ulrich H. .

NATURE, 2007, 450 (7166) :110-+

[16] Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection [J].

Lawrence, CW ;

Braciale, TJ .

JOURNAL OF IMMUNOLOGY, 2004, 173 (02) :1209-1218

[17] Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection [J].

Legge, KL ;

Braciale, TJ .

IMMUNITY, 2003, 18 (02) :265-277

[18] Localization, quantitation, and in situ detection of specific peptide MHC class I complexes using a monoclonal antibody [J].

Porgador, A ;

Yewdell, JW ;

Deng, YP ;

Bennink, JR ;

Germain, RN .

IMMUNITY, 1997, 6 (06) :715-726

[19] CONTROL OF INFLUENZA AND POLIOMYELITIS WITH KILLED VIRUS-VACCINES [J].

SALK, J ;

SALK, D .

SCIENCE, 1977, 195 (4281) :834-847

[20] Cutting edge:: Conventional CD8α+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1 [J].

Smith, CM ;

Belz, GT ;

Wilson, NS ;

Villadangos, JA ;

Shortman, K ;

Carbone, FR ;

Heath, WR .

JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4437-4440

← 1 2 3 →