Cutting Edge: Antigen Presentation to CD8 T Cells after influenza A Virus Infection

被引：25

作者：

Ingulli, Elizabeth ^{[1
]}

Funatake, Castle ^{[2
,3
]}

Jacovetty, Erica L. ^{[1
]}

Zanetti, Maurizio ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Immunol Lab, Dept Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CD8-ALPHA(+) DENDRITIC CELLS; LYMPH-NODES; LUNG; MIGRATION; IMMUNITY; MICE; DIFFERENTIATION; POPULATIONS; ACTIVATION; NAIVE;

D O I：

10.4049/jimmunol.182.1.29

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, presentation was found to be mediated by a CD11b(+) DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection. The Journal of Immunology, 2009, 182: 29-33.

引用

页码：29 / 33

页数：5

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