Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus

被引：167
|
作者：
Khan, IA [1 ]
Mirza, ZM [1 ]
Kumar, A [1 ]
Verma, V [1 ]
Qazi, GN [1 ]
机构：
[1] Reg Res Lab, Div Biotechnol, Jammu 180001, India
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期
关键词：
D O I：
10.1128/AAC.50.2.810-812.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.
引用
收藏
页码：810 / 812
页数：3
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