Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus

被引：171

作者：

Khan, IA ^{[1
]}

Mirza, ZM ^{[1
]}

Kumar, A ^{[1
]}

Verma, V ^{[1
]}

Qazi, GN ^{[1
]}

机构：

[1] Reg Res Lab, Div Biotechnol, Jammu 180001, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期

关键词：

D O I：

10.1128/AAC.50.2.810-812.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.

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页码：810 / 812

页数：3

相关论文

共 21 条

[1] SCIENTIFIC EVIDENCE ON THE ROLE OF AYURVEDIC HERBALS ON BIOAVAILABILITY OF DRUGS [J].

ATAL, CK ;

ZUTSHI, U ;

RAO, PG .

JOURNAL OF ETHNOPHARMACOLOGY, 1981, 4 (02) :229-232

[2]

ATAL CK, 1985, J PHARMACOL EXP THER, V232, P258

[3] Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. [J].

Badmaev, V ;

Majeed, M ;

Norkus, EP .

NUTRITION RESEARCH, 1999, 19 (03) :381-388

[4] Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae [J].

Baranova, NN ;

Neyfakh, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (06) :1396-1398

[5] Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4 [J].

Bhardwaj, RK ;

Glaeser, H ;

Becquemont, L ;

Klotz, U ;

Gupta, SK ;

Fromm, MF .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 302 (02) :645-650

[6] Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae [J].

Brenwald, NP ;

Gill, MJ ;

Wise, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (08) :2032-2035

[7]

Drugeon H. B., 1999, Journal of Antimicrobial Chemotherapy, V43, P55, DOI 10.1093/jac/43.suppl_3.55

[8]

Eliopolous GM., 1996, Antibiotics in laboratory medicine, P330

[9]

Eliopoulos G M, 1995, Drugs, V49 Suppl 2, P48

[10] A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus [J].

Gibbons, S ;

Oluwatuyi, M ;

Kaatz, GW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (01) :13-17