Galanthamine

被引：59
作者：
Fulton, B [1 ]
Benfield, P [1 ]
机构：
[1] ADIS INT LTD, AUCKLAND 10, NEW ZEALAND
来源：
DRUGS & AGING | 1996年 / 9卷 / 01期
关键词：
D O I：
10.2165/00002512-199609010-00006
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
· Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. · Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue. · Galanthamine attenuates drug- and lesion-induced cognitive deficits in animal models of learning and memory. · Preliminary results in patients with Alzheimer's disease have reported galanthamine to be associated with a reduction in cognitive deterioration on some neuropsychiatric rating scales. · Nausea and vomiting are the most commonly reported adverse effects; liver toxicity has not been reported to date.
引用
收藏
页码：60 / 65
页数：6
相关论文
共 23 条
[1]   PHARMACOKINETICS OF GALANTHAMINE IN HUMANS AND CORRESPONDING CHOLINESTERASE INHIBITION [J].
BICKEL, U ;
THOMSEN, T ;
WEBER, W ;
FISCHER, JP ;
BACHUS, R ;
NITZ, M ;
KEWITZ, H .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 50 (04) :420-428
[2]   GALANTHAMINE - PHARMACOKINETICS, TISSUE DISTRIBUTION AND CHOLINESTERASE INHIBITION IN BRAIN OF MICE [J].
BICKEL, U ;
THOMSEN, T ;
FISCHER, JP ;
WEBER, W ;
KEWITZ, H .
NEUROPHARMACOLOGY, 1991, 30 (05) :447-454
[3]  
BONNER J, 1995, NEW SCI, V11, P145
[4]   EFFECTS OF 4 NONCHOLINERGIC COGNITIVE ENHANCERS IN COMPARISON WITH TACRINE AND GALANTHAMINE ON SCOPOLAMINE-INDUCED AMNESIA IN RATS [J].
CHOPIN, P ;
BRILEY, M .
PSYCHOPHARMACOLOGY, 1992, 106 (01) :26-30
[5]  
DALBIANCO P, 1991, J NEURAL TRANSM-GEN, P59
[6]   D-CYCLOSERINE ATTENUATES SCOPOLAMINE-INDUCED LEARNING AND MEMORY DEFICITS IN RATS [J].
FISHKIN, RJ ;
INCE, ES ;
CARLEZON, WA ;
DUNN, RW .
BEHAVIORAL AND NEURAL BIOLOGY, 1993, 59 (02) :150-157
[7]   EFFECT OF THE CHOLINESTERASE INHIBITING SUBSTANCE GALANTHAMINE ON HUMAN EEG AND VISUAL EVOKED-POTENTIALS [J].
HOLL, G ;
STRASCHILL, M ;
THOMSEN, T ;
FISCHER, JP ;
KEWITZ, H .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1992, 82 (06) :445-452
[8]  
KEWITZ H, 1994, 3 INT SPRINGF S ADV, P39
[9]  
KEWITZ H, 1994, NEUROPSYCHOP S 2 MAY, V10, P130
[10]   PHARMACOKINETICS OF GALANTHAMINE HYDROBROMIDE AFTER SINGLE SUBCUTANEOUS AND ORAL DOSAGE IN HUMANS [J].
MIHAILOVA, D ;
YAMBOLIEV, I ;
ZHIVKOVA, Z ;
TENCHEVA, J ;
JOVOVICH, V .
PHARMACOLOGY, 1989, 39 (01) :50-58
123