Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization

被引：27

作者：

Schlachet, Inbar ^{[1
]}

Trousil, Jiri ^{[2
,3
]}

Rak, Dmytro ^{[4
]}

Knudsen, Kenneth D. ^{[5
]}

Pavlova, Ewa ^{[2
]}

Nystrom, Bo ^{[6
]}

Sosnik, Alejandro ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Mat Sci & Engn, Lab Pharmaceut Nanomat Sci, IL-320003 Haifa, Israel

[2] Czech Acad Sci, Inst Macromol Chem, Heyrovskeho Namesti 2, Prague 16206 6, Czech Republic

[3] Charles Univ Prague, Fac Sci, Dept Analyt Chem, Hlavova 8, Prague 12843 2, Czech Republic

[4] Slovak Acad Sci, Inst Expt Phys, Watsonova 47, Kosice 04001, Slovakia

[5] Inst Energy Technol, Dept Phys, POB 40, N-2027 Kjeller, Norway

[6] Univ Oslo, Dept Chem, POB 1033, N-0315 Oslo, Norway

来源：

CARBOHYDRATE POLYMERS | 2019年 / 212卷

基金：

以色列科学基金会;

关键词：

Chitosan-graft-poly(methyl methacrylate) copolymers; Self-assembly; Amphiphilic polymeric nanoparticles; Small-angle neutron scattering (SANS); Static light scattering (SLS) and dynamic light scattering (DLS); BLOCK-COPOLYMER MICELLES; POLYMERIC MICELLES; DELIVERY-SYSTEMS; CHITOSAN; DESIGN; SCATTERING; STABILITY; BARRIERS;

D O I：

10.1016/j.carbpol.2019.02.022

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this work, we synthesized and characterized the self-assembly behavior of a chitosan-poly(methyl methacrylate) graft copolymer and the properties of the formed nanoparticles by static and dynamic light scattering, small-angle neutron scattering, and transmission electron microscopy. Overall, our results indicate that the hydrophobization of the chitosan side-chain with PMMA leads to a complex array of small unimolecular and/or small-aggregation number "building blocks" that further self-assemble into larger amphiphilic nanoparticles.

引用

页码：412 / 420

页数：9

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