Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer's Disease and CNS-Related Disorders

被引：26

作者：

Alexiou, Athanasios ^{[1
,2
]}

Soursou, Georgia ^{[3
]}

Chatzichronis, Stylianos ^{[2
,4
]}

Gasparatos, Ermis ^{[5
]}

Kamal, Mohammad Amjad ^{[1
,6
,7
]}

Yarla, Nagendra Sastry ^{[8
]}

Perveen, Asma ^{[9
]}

Barreto, George E. ^{[10
,11
]}

Ashraf, Ghulam Md ^{[6
]}

机构：

[1] Novel Global Community Educ Fdn, Hebersham, Australia

[2] AFNP Med Austria, Haidingergasse 29, A-1030 Vienna, Austria

[3] Univ Crete, Sch Med, Bioinformat Program, Iraklion, Greece

[4] Natl & Kapodistrian Univ Athens, Dept Informat & Telecommun, Bioinformat Program, Athens, Greece

[5] City Unity Coll Athens, Dept Psychol, Athens, Greece

[6] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia

[7] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia

[8] GITAM Univ, Inst Sci, Dept Biochem & Bioinformat, Visakhapatnam 530045, Andhra Pradesh, India

[9] Glocal Univ, Mirzapur Pole, Sch Life Sci, Saharanpur, Uttar Pradesh, India

[10] Pontificia Univ Javeriana, Dept Nutr & Bioquim, Fac Ciencias, Bogota, DC, Colombia

[11] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile

来源：

MOLECULAR NEUROBIOLOGY | 2019年 / 56卷 / 06期

关键词：

Mitochondria; Mitochondrial dynamics; Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Oxidative stress; POTENTIAL THERAPEUTIC TARGET; OXIDATIVE DAMAGE; PROTECTS MITOCHONDRIA; UP-REGULATION; DYSFUNCTION; CELLS; BRAIN; FUSION; BETA; ABNORMALITIES;

D O I：

10.1007/s12035-018-1397-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Data obtained from several studies have shown that mitochondria are involved and play a central role in the progression of several distinct pathological conditions. Morphological alterations and disruptions on the functionality of mitochondria may be related to metabolic and energy deficiency in neurons in a neurodegenerative disorder. Several recent studies demonstrate the linkage between neurodegeneration and mitochondrial dynamics in the spectrum of a promising era called precision mitochondrial medicine. In this review paper, an analysis of the correlation between mitochondria, Alzheimer's disease, and other central nervous system (CNS)-related disorders like the Parkinson's disease and the autism spectrum disorder is under discussion. The role of GTPases like the mfn1, mfn2, opa1, and dlp1 in mitochondrial fission and fusion is also under investigation, influencing mitochondrial population and leading to oxidative stress and neuronal damage.

引用

页码：4530 / 4538

页数：9

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