Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents

被引：19

作者：

Rozema, E. ^{[1
]}

van Dam, A. D. ^{[2
]}

Sips, H. C. M. ^{[2
]}

Verpoorte, R. ^{[1
]}

Meijer, O. C. ^{[2
]}

Kooijman, S. ^{[2
]}

Choi, Y. H. ^{[1
]}

机构：

[1] Leiden Univ, Inst Biol, Nat Prod Lab, NL-2333 BE Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Med, Div Endocrinol, NL-2300 RC Leiden, Netherlands

来源：

RSC ADVANCES | 2015年 / 5卷 / 75期

关键词：

SALICYLATE; ASPIRIN;

D O I：

10.1039/c5ra10196d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural deep eutectic solvents (NADES) are recently developed green solvents that are attractive for their great solubilising power and intrinsic lack of toxicity. In this paper we report the results of a study on the feasibility and benefits of dissolving the poorly water-soluble salsalate in a NADES composed of 1,2-propanediol-choline-water as an alternative to DMSO for functional in vitro assays. The increase in solubility allows an extension of the range of the dose-response curve of salsalate-induced activation of brown adipocytes.

引用

页码：61398 / 61401

页数：4

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