Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design

被引：0
作者：
Qayyum, Abbas Ali [1 ]
Haack-Sorensen, Mandana [2 ]
Mathiasen, Anders Bruun [1 ]
Jorgensen, Erik [1 ]
Ekblond, Annette [2 ]
Kastrup, Jens [1 ,2 ]
机构：
[1] Univ Copenhagen Hosp, Rigshosp, Ctr Heart, Cardiac Catheterizat Lab 2014, DK-2100 Copenhagen O, Denmark
[2] Univ Copenhagen Hosp, Rigshosp, Ctr Heart, Cardiol Stem Cell Lab, DK-2100 Copenhagen O, Denmark
来源：
REGENERATIVE MEDICINE | 2012年 / 7卷 / 03期
关键词：
adipose-derived stromal cell; adipose tissue; cardiac repair; chronic ischemic heart disease; double-blind; intramyocardial injection; mesenchymal stem cell; mesenchymal stromal cell; MyStromalCell Trial; placebo-controlled trial; randomized; vascular endothelial growth factor; STEM-CELLS; REFRACTORY ANGINA; INTRAMYOCARDIAL INJECTION; TISSUE; DIFFERENTIATION; THERAPY; CULTURE; INFARCTION; PECTORIS; DISEASE;
D O I：
10.2217/RME.12.17
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Adipose tissue represents an abundant, accessible source of multipotent adipose-derived stromal cells (ADSCs). Animal studies have suggested that ADSCs have the potential to differentiate in vivo into endothelial cells and cardiomyocytes. This makes ADSCs a promising new cell source for regenerative therapy to replace injured tissue by creating new blood vessels and cardiomyocytes in patients with chronic ischemic heart disease. The aim of this special report is to review the present preclinical data leading to clinical stem cell therapy using ADSCs in patients with ischemic heart disease. In addition, we give an introduction to the first-in-man clinical trial, MyStromalCell Trial, which is a prospective, randomized, double-blind, placebo-controlled study using culture-expanded ADSCs obtained from adipose-derived cells from abdominal adipose tissue and stimulated with VEGF-A(165) the week before treatment.
引用
收藏
页码：421 / 428
页数：8
相关论文
共 40 条
  • [1] Release of biomarkers of myocardial damage after direct intramyocardial injection of genes and stem cells via the percutaneous transluminal route
    Baldazzi, Federica
    Jorgensen, Erik
    Ripa, Rasmus S.
    Kastrup, Jens
    [J]. EUROPEAN HEART JOURNAL, 2008, 29 (15) : 1819 - 1826
  • [2] Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro
    Bochev, Ivan
    Elmadjian, Gabriel
    Kyurkchiev, Dobroslav
    Tzvetanov, Liubomir
    Altankova, Iskra
    Tivchev, Peter
    Kyurkchiev, Stanimir
    [J]. CELL BIOLOGY INTERNATIONAL, 2008, 32 (04) : 384 - 393
  • [3] Duckers E., 2010, 7 INT S STEM CELL TH
  • [4] Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes
    Fraser J.K.
    Schreiber R.
    Strem B.
    Zhu M.
    Alfonso Z.
    Wulur I.
    Hedrick M.H.
    [J]. Nature Clinical Practice Cardiovascular Medicine, 2006, 3 (Suppl 1): : S33 - S37
  • [5] Mesenchymal stromal cell derived endothelial progenitor treatment in patients with refractory angina
    Friis, Tina
    Haack-Sorensen, Mandana
    Mathiasen, Anders B.
    Ripa, Rasmus S.
    Kristoffersen, Ulrik S.
    Jorgensen, Erik
    Hansen, Louise
    Bindslev, Lene
    Kjaer, Andreas
    Hesse, Birger
    Dickmeiss, Ebbe
    Kastrup, Jens
    [J]. SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2011, 45 (03) : 161 - 168
  • [6] Comparison of mesenchymal stromal cells from young healthy donors and patients with severe chronic coronary artery disease
    Friis, Tina
    Haack-Sorensen, Mandana
    Hansen, Susanne Kofoed
    Hansen, Louise
    Bindslev, Lene
    Kastrup, Jens
    [J]. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2011, 71 (03) : 193 - 202
  • [7] Surface protein characterization of human adipose tissue-derived stromal cells
    Gronthos, S
    Franklin, DM
    Leddy, HA
    Robey, PG
    Storms, RW
    Gimble, JM
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2001, 189 (01) : 54 - 63
  • [8] Comparison of different culture conditions for human mesenchymal stromal cells for clinical stem cell therapy
    Haack-Sorensen, M.
    Friis, T.
    Bindslev, L.
    Mortensen, S.
    Johnsen, H. E.
    Kastrup, J.
    [J]. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2008, 68 (03) : 192 - 203
  • [9] Haack-Sorensen M., 2012, CELL TRANSP IN PRESS
  • [10] Stem cells from adipose tissue allow challenging new concepts for regenerative medicine
    Helder, Marco N.
    Knippenberg, Marlene
    Klein-Nulend, Jenneke
    Wuisman, Paul I. J. M.
    [J]. TISSUE ENGINEERING, 2007, 13 (08): : 1799 - 1808
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