Striatal microcircuitry and movement disorders

被引：147

作者：

Gittis, Aryn H. ^{[1
]}

Kreitzer, Anatol C. ^{[1
,2
,3
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

来源：

TRENDS IN NEUROSCIENCES | 2012年 / 35卷 / 09期

基金：

美国国家卫生研究院;

关键词：

interneuron; basal ganglia; Parkinson's disease; Huntington's disease; dystonia; Tourette syndrome; MEDIUM SPINY NEURONS; FAST-SPIKING INTERNEURONS; EXTERNAL GLOBUS-PALLIDUS; BASAL GANGLIA OUTPUT; PROJECTION NEURONS; GABAERGIC INTERNEURONS; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; ELECTROPHYSIOLOGICAL PROPERTIES; CHOLINERGIC INTERNEURONS;

D O I：

10.1016/j.tins.2012.06.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The basal ganglia network serves to integrate information about context, actions, and outcomes to shape the behavior of an animal based on its past experience. Clinically, the basal ganglia receive the most attention for their role in movement disorders. Recent advances in technology have opened new avenues of research into the structure and function of basal ganglia circuits. One emerging theme is the importance of GABAergic interneurons in coordinating and regulating network function. Here, we discuss evidence that changes in striatal GABAergic microcircuits contribute to basal ganglia dysfunction in several movement disorders. Because interneurons are genetically and neurochemically unique from striatal projection neurons, they may provide promising therapeutic targets for the treatment of a variety of striatal-based disorders.

引用

页码：557 / 564

页数：8

共 115 条

[1] Recent advances in Tourette syndrome research [J].