The application of three-dimensional cell culture in clinical medicine

被引：8
作者：
Chen, Qiao [1 ]
Wang, Youbin [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Plast Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2020年 / 42卷 / 11期
基金：
中国国家自然科学基金;
关键词：
In vivo; Three-dimensional cell cultures; Scaffold-based techniques; Scaffold-free techniques; Clinical application; Translational medicine; GLUCOSE DIFFUSIVITY; STEM-CELLS; DIFFERENTIATION; HYDROGELS; TUMOR; SPHEROIDS; STIFFNESS; MATRIX; DRUG; RGD;
D O I：
10.1007/s10529-020-03003-y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Three-dimensional cell culture technology is a novel cell culture technology, which can simulate the growth state of cells in vivo by scaffolds or special devices. Cells can form tissues or organs in vitro. It combines some advantages of traditional cell experiments and animal model experiments. Because of its advantages, it is widely used in clinical medical research, including research on stem cell differentiation, research on cell behavior, migration and invasion, study on microenvironment, study on drug sensitivity and radio-sensitivity of tumor cells, etc. In this paper, the evolution and classification of three-dimensional cell culture are reviewed, also the advantages and shortages are compared. The application of three-dimensional cell culture in clinical medicine are summarized to provide an insight into translational medicine.
引用
收藏
页码：2071 / 2082
页数：12
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