The application of three-dimensional cell culture in clinical medicine

被引：7
|
作者：
Chen, Qiao [1 ]
Wang, Youbin [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Plast Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2020年 / 42卷 / 11期
基金：
中国国家自然科学基金;
关键词：
In vivo; Three-dimensional cell cultures; Scaffold-based techniques; Scaffold-free techniques; Clinical application; Translational medicine; GLUCOSE DIFFUSIVITY; STEM-CELLS; DIFFERENTIATION; HYDROGELS; TUMOR; SPHEROIDS; STIFFNESS; MATRIX; DRUG; RGD;
D O I：
10.1007/s10529-020-03003-y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Three-dimensional cell culture technology is a novel cell culture technology, which can simulate the growth state of cells in vivo by scaffolds or special devices. Cells can form tissues or organs in vitro. It combines some advantages of traditional cell experiments and animal model experiments. Because of its advantages, it is widely used in clinical medical research, including research on stem cell differentiation, research on cell behavior, migration and invasion, study on microenvironment, study on drug sensitivity and radio-sensitivity of tumor cells, etc. In this paper, the evolution and classification of three-dimensional cell culture are reviewed, also the advantages and shortages are compared. The application of three-dimensional cell culture in clinical medicine are summarized to provide an insight into translational medicine.
引用
收藏
页码：2071 / 2082
页数：12
相关论文
共 50 条
  • [1] The application of three-dimensional cell culture in clinical medicine
    Qiao Chen
    Youbin Wang
    Biotechnology Letters, 2020, 42 : 2071 - 2082
  • [2] Progress on three-dimensional cell culture technology and their application
    Lu X.
    Liu X.
    Zhong H.
    Zhang W.
    Yu S.
    Guan R.
    Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering, 2023, 40 (03): : 602 - 608
  • [3] Application of nanomaterials in three-dimensional stem cell culture
    Aziz, Shiva Gholizadeh-Ghaleh
    Pashaiasl, Maryam
    Khodadadi, Khodadad
    Ocheje, Onuche
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (11) : 18550 - 18558
  • [4] Bioreactor for application of subatmospheric pressure to three-dimensional cell culture
    Wilkes, Robert P.
    McNulty, Amy K.
    Feeley, Teri D.
    Schmidt, Marisa A.
    Kieswetter, Kris
    TISSUE ENGINEERING, 2007, 13 (12): : 3003 - 3010
  • [5] Three-dimensional perfused cell culture
    Li, Zhaohui
    Cui, Zhanfeng
    BIOTECHNOLOGY ADVANCES, 2014, 32 (02) : 243 - 254
  • [6] Three-dimensional cell culture systems
    Cordes, N.
    RADIOTHERAPY AND ONCOLOGY, 2017, 123 : S101 - S102
  • [7] Application of three-dimensional cell culture technology in screening anticancer drugs
    Sun, Yaqian
    Ma, Haiyang
    BIOTECHNOLOGY LETTERS, 2023, 45 (09) : 1073 - 1092
  • [8] Application of three-dimensional cell culture technology in screening anticancer drugs
    Yaqian Sun
    Haiyang Ma
    Biotechnology Letters, 2023, 45 : 1073 - 1092
  • [9] Three-Dimensional Micro Vibration Stage and Its Application to Cell Culture
    Konno, Ken-ichi
    Kosawada, Tadashi
    Sato, Ryota
    Feng, Zhonggang
    Hozumi, Yasukazu
    Goto, Kaoru
    6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3, 2010, 31 : 1409 - +
  • [10] Application of three-dimensional printing in interventional medicine
    Geng Zhou
    Weidong Liu
    Yi Zhang
    Wenquan Gu
    Minghua Li
    Chuan Lu
    Ran Zhou
    Yichen Che
    Haitao Lu
    Yueqi Zhu
    Gaojun Teng
    Yongde Cheng
    Journal of Interventional Medicine, 2020, 3 (01) : 1 - 16
12345