Hyaluronic acid in digestive cancers

被引：27
作者：
Wu, Ruo-Lin [1 ,3 ]
Huang, Lei [2 ,4 ]
Zhao, Hong-Chuan [1 ]
Geng, Xiao-Ping [1 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Dept Hepatopancreatobiliary Surg, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hefei 230022, Peoples R China
[3] Med Fac Mannheim, Univ Heidelberg, Res Ctr Biomed & Med Technol Mannheim CBTM, D-68167 Mannheim, Germany
[4] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2017年 / 143卷 / 01期
关键词：
Hyaluronan; Receptor; Digestive cancer; Tumor growth; Epithelial-mesenchymal transition; Metastasis; Prognosis; EPITHELIAL-MESENCHYMAL TRANSITION; ANCHORAGE-INDEPENDENT GROWTH; MOLECULAR-WEIGHT HYALURONAN; COLON-CARCINOMA CELLS; CD44; VARIANT; 9; IN-VITRO; TUMOR-CELLS; HEPATOCELLULAR-CARCINOMA; INTRACELLULAR DELIVERY; GASTRIC-CANCER;
D O I：
10.1007/s00432-016-2213-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose Hyaluronan (HA), an extracellular and peri-cellular glycosaminoglycan with a large molecular weight, plays an important role in cancer growth and metastasis. The aim of this study was to summarize the biological roles and regulation of HA and small HA fragments, and their metabolismn enzymes and receptors in human digestive cancers. Methods A systematic literature search mainly focusing on the biological roles of HA in the development and progression of human digestive cancers was performed using electronic databases. Results The correlation between HA accumulation and tumor progression has been shown in various digestive cancers. HA and HA fragment-tumor cell interaction could activate the downstream signaling pathways, promoting cell proliferation, adhesion, migration and invasion, and inducing angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like property, and chemora-dioresistance in digestive cancers. Conclusions A better insight into the mechanism of HA and HA fragment involvement in digestive cancer progression might be useful for the development of novel biomarkers and therapeutic strategies.
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页码：1 / 16
页数：16
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