Transcriptional regulation of the growth-regulated oncogene α gene by early growth response protein-1 in response to tumor necrosis factor α stimulation

被引：31

作者：

Shin, Soon Young ^{[1
,2
]}

Lee, Jong Min ^{[1
]}

Lim, Yoongho ^{[2
,3
]}

Lee, Young Han ^{[1
,2
]}

机构：

[1] Konkuk Univ, Dept Biol Sci, Coll Biol Sci & Biotechnol, Seoul 143701, South Korea

[2] Konkuk Univ, Canc & Metab Inst, Seoul 143701, South Korea

[3] Konkuk Univ, BMIC, Div Biosci & Biotechnol, Seoul 143701, South Korea

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2013年 / 1829卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Egr-1; GRO alpha; TNF alpha; MAPK; Transcriptional regulation; Tumor microenvironment; NF-KAPPA-B; CXC CHEMOKINES; FACTOR EGR-1; ESOPHAGEAL CANCER; HUMAN FIBROBLASTS; PROSTATE-CANCER; GASTRIC-CANCER; CELLS; EXPRESSION; INFLAMMATION;

D O I：

10.1016/j.bbagrm.2013.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Growth-regulated oncogene alpha (GRO alpha) plays an important role in a wide range of normal and pathological conditions, including inflammation, angiogenesis, wound healing, tumor invasion, and metastasis. Egr-1 is a member of the zinc-finger transcription factor family induced by diverse stimuli, including TNF alpha. However, the role of Egr-1 in GRO alpha expression was previously unknown. This study shows that Egr-1 directly binds to the GRO alpha promoter and transactivates the GRO alpha gene. Silencing of Egr-1 by expression of Egr-1 siRNA abrogated TNF alpha-induced GRO alpha transcription. We also found that Egr-1 mediates ERK and JNK MAPK-dependent GRO alpha transcription upon TNF alpha stimulation. Our findings suggest that Egr-1 may play an important role in tumor development through transactivation of the GRO alpha gene in response to TNF alpha within the tumor microenvironment. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1066 / 1074

页数：9

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