Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment

被引：37
作者：
Koh, S
Nelson, MD
Kovanlikaya, A
Chen, LS
机构：
[1] Childrens Hosp Los Angeles, Div Neurol, Los Angeles, CA 90027 USA
[2] Childrens Hosp Los Angeles, Div Radiol, Los Angeles, CA 90027 USA
[3] Univ So Calif, Los Angeles, CA USA
来源：
PEDIATRIC NEUROLOGY | 1999年 / 21卷 / 02期
关键词：
D O I：
10.1016/S0887-8994(99)00040-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children. Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity. Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery, Gadolinium enhancement of anterior lmnbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms, The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic complication associated with intrathecal methotrexate treatment, (C) 1999 by Elsevier Science Inc, All rights reserved.
引用
收藏
页码：576 / 578
页数：3
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