Nitric oxide and cell death in liver cancer cells

被引：35

作者：

Muntane, Jordi ^{[1
]}

De la Rosa, Angel J. ^{[1
]}

Marin, Luis M. ^{[2
]}

Padillo, Francisco J. ^{[2
]}

机构：

[1] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS, Seville 41013, Spain

[2] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Gen Surg,IBiS, Seville 41013, Spain

来源：

MITOCHONDRION | 2013年 / 13卷 / 03期

关键词：

Liver; Cancer; Nitrosative stress; Nitric oxide; Hepatocytes; Therapy; MITOCHONDRIAL RESPIRATORY-CHAIN; ENDOTHELIAL GROWTH-FACTOR; PROTEIN S-NITROSYLATION; HUMAN BREAST-CANCER; JUN DNA-BINDING; NF-KAPPA-B; SYNTHASE EXPRESSION; GUANYLYL CYCLASE; RELAXING FACTOR; SMOOTH-MUSCLE;

D O I：

10.1016/j.mito.2012.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nitric oxide (NO) is a lipophillic, highly diffusible, and short-lived physiological messenger which regulates a variety of physiopathological responses. NO may exert its cellular action through cGMP-dependent and cGMP-independent pathways which includes different postranslational modifications. The effect of NO in cancer depends on the activity and localization of NOS isoforms, concentration and duration of NO exposure, cellular sensitivity, and hypoxia/re-oxygenation process. NO regulates critical factors such as the hypoxia inducible factor-1 (HIF-1) and p53 generally leading to growth arrest, apoptosis or adaptation. NO sensitizes hepatoma cells to chemotherapeutic compounds probably through increased p53 and cell death receptor expressions. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：257 / 262

页数：6

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