Biomaterial microarchitecture: a potent regulator of individual cell behavior and multicellular organization

被引:52
作者
Hogrebe, Nathaniel J. [1 ]
Reinhardt, James W. [1 ]
Gooch, Keith J. [1 ,2 ]
机构
[1] Ohio State Univ, Dept Biomed Engn, 270 Bevis Hall 1080 Carmack Rd, Columbus, OH 43210 USA
[2] Ohio State Univ, Davis Heart Lung Res Inst, 473 W 12th Ave, Columbus, OH 43210 USA
基金
美国国家科学基金会;
关键词
microarchitecture; fibrous matrix; stromal extracellular matrix; collagen fiber; 3D cell culture; POROUS CHITOSAN SCAFFOLDS; IN-VITRO CHONDROGENESIS; MESENCHYMAL STEM-CELLS; EXTRACELLULAR-MATRIX; MECHANICAL-PROPERTIES; COLLAGEN MATRIX; FIBRILLAR COLLAGEN; FIBRONECTIN FIBRILLOGENESIS; CAPILLARY MORPHOGENESIS; MICROVASCULAR NETWORKS;
D O I
10.1002/jbm.a.35914
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Insoluble cues from a cell's surrounding microenvironment have increasingly been shown to be important regulators of cell behavior. The microarchitecture of biomaterials used for 3D cell encapsulation, however, is often underappreciated as an important insoluble factor guiding cell activity. In this review, we illustrate that the subcellular physical features of a scaffold influence a range of cell behaviors, including morphology, cytoskeletal organization, migration, matrix remodeling, and long-range force transmission. We emphasize that the microarchitecture of stromal extracellular matrix (ECM)specifically the fact that it consists of a network of long interconnecting fibers with micron and nanometer-sized diametersis an important determinant of how cells naturally interact with their surrounding matrix and each other. Synthetic biomaterials with a microarchitecture similar to stromal ECM can support analogous cellular responses, suggesting that this fibrous microarchitecture is a key regulator of these cell behaviors. Drawing upon examples from in vitro, in silico, and in vivo studies, we compare these behaviors in fibrous matrices to those of cells cultured within nanoporous matrices (e.g., alginate and PEG gels) as well as macroporous scaffolds to highlight key differences in the cellular response to each type of microarchitecture. Understanding how microarchitecture affects cell behavior can lead to more efficient biomaterial selection when designing tissue engineered scaffolds for therapeutic applications. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 640-661, 2017.
引用
收藏
页码:640 / 661
页数:22
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