Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

被引：27

作者：

Cui, Wenpeng ^{[1
,2
]}

Bai, Yang ^{[2
,3
]}

Luo, Ping ^{[1
]}

Miao, Lining ^{[1
]}

Cai, Lu ^{[2
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Nephrol, Changchun 130041, Jilin Province, Peoples R China

[2] Univ Louisville, Dept Pediat, KCHRI, Louisville, KY 40202 USA

[3] Peoples Hosp Jilin Prov, Dept Cardiol, Changchun 130021, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2013年 / 2013卷

基金：

中国国家自然科学基金;

关键词：

UBIQUITIN-PROTEASOME SYSTEM; ANTIOXIDANT RESPONSE ELEMENT; NF-KAPPA-B; AS4.1 JUXTAGLOMERULAR CELLS; TRANSCRIPTION FACTOR NRF2; CHRONIC KIDNEY-DISEASE; ENDOTHELIAL DYSFUNCTION; HEME OXYGENASE-1; GENE-EXPRESSION; INFLAMMATORY RESPONSE;

D O I：

10.1155/2013/306073

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

So far, cardiovascular and renal diseases have brought us not only huge economic burden but also serious society problems. Since effective therapeutic strategies are still limited, to find new methods for the prevention or therapy of these diseases is important. Oxidative stress has been found to play a critical role in the initiation and progression of cardiovascular and renal diseases. In addition, activation of nuclear-factor-E2-related-factor-2- (Nrf2-) antioxidant-responsive element (ARE) signaling pathway protects cells and tissues from oxidative damage. As a proteasomal inhibitor, MG132 was reported to activate Nrf2 expression and function, which was accompanied with significant preventive and/or therapeutic effect on cardiovascular and renal diseases under most conditions; therefore, MG132 seems to be a potentially effective drug to be used in the prevention of oxidative damage. In this paper, we will summarize the information available regarding the effect of MG132 on oxidative stress-induced cardiovascular and renal damage, especially through Nrf2-ARE signaling pathway.

引用

页数：10

共 131 条

[91] Regulatory mechanisms controlling gene expression mediated by the antioxidant response element [J].

Nguyen, T ;

Sherratt, PJ ;

Pickett, CB .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2003, 43 :233-260

[92] Insights into the molecular architecture of the 26S proteasome [J].

Nickell, Stephan ;

Beck, Florian ;

Scheres, Sjors H. W. ;

Korinek, Andreas ;

Foerster, Friedrich ;

Lasker, Keren ;

Mihalache, Oana ;

Sun, Na ;

Nagya, Istvan ;

Sali, Andrej ;

Plitzko, Juergen M. ;

Carazo, Jose-Maria ;

Mann, Matthias ;

Baumeister, Wolfgang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (29) :11943-11947

[93] Prevalence and characteristics of individuals with chronic kidney disease in a large health maintenance organization [J].

Nissenson, AR ;

Pereira, BJG ;

Collins, AJ ;

Steinberg, EP .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2001, 37 (06) :1177-1183

[94] Niemann-Pick type C disease and Alzheimer's disease - The APP-endosome connection fattens up [J].

Nixon, RA .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (03) :757-761

[95] Zinc Supplementation Attenuates Metallothionein and Oxidative Stress Changes in Kidney of Streptozotocin-Induced Diabetic Rats [J].

Ozcelik, Dervis ;

Naziroglu, Mustafa ;

Tuncdemir, Matem ;

Celik, Omer ;

Ozturk, Melek ;

Flores-Arce, M. F. .

BIOLOGICAL TRACE ELEMENT RESEARCH, 2012, 150 (1-3) :342-349

[96] MG132, a proteasome inhibitor, induces human pulmonary fibroblast cell death via increasing ROS levels and GSH depletion [J].

Park, Woo Hyun ;

Kim, Suhn Hee .

ONCOLOGY REPORTS, 2012, 27 (04) :1284-1291

[97] Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes [J].

Pergola, Pablo E. ;

Raskin, Philip ;

Toto, Robert D. ;

Meyer, Colin J. ;

Huff, J. Warren ;

Grossman, Eric B. ;

Krauth, Melissa ;

Ruiz, Stacey ;

Audhya, Paul ;

Christ-Schmidt, Heidi ;

Wittes, Janet ;

Warnock, David G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (04) :327-336

[98] Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress [J].

Pickering, Andrew M. ;

Linder, Robert A. ;

Zhang, Hongqiao ;

Forman, Henry J. ;

Davies, Kelvin J. A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (13) :10021-10031

[99] The Lipid Peroxidation By-Product 4-Hydroxy-2-Nonenal (4-HNE) Induces Insulin Resistance in Skeletal Muscle through Both Carbonyl and Oxidative Stress [J].

Pillon, Nicolas J. ;

Croze, Marine L. ;

Vella, Roxane E. ;

Soulere, Laurent ;

Lagarde, Michel ;

Soulage, Christophe O. .

ENDOCRINOLOGY, 2012, 153 (05) :2099-2111

[100] Protein modification as oxidative stress marker in normal and pathological human seminal plasma [J].

Piomboni, Paola ;

Stendardi, Anita ;

Gambera, Laura ;

Tatone, Carla ;

Coppola, Lamberto ;

De Leo, Vincenzo ;

Focarelli, Riccardo .

REDOX REPORT, 2012, 17 (05) :227-232

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