Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts

被引：51

作者：

Jakobsson, Lars ^{[1
]}

van Meeteren, Laurens A. ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, SE-17177 Stockholm, Sweden

[2] Utrecht Univ Appl Sci, Inst Life Sci & Chem, NL-2317 JE Utrecht, Netherlands

来源：

EXPERIMENTAL CELL RESEARCH | 2013年 / 319卷 / 09期

基金：

瑞典研究理事会;

关键词：

TGF-beta; Angiogenesis; Vascular-stability; Endothelial; Conditional; HEREDITARY HEMORRHAGIC TELANGIECTASIA; SMOOTH-MUSCLE-CELLS; RECEPTOR-LIKE KINASE-1; YOLK-SAC VASCULATURE; TGF-BETA; ENDOTHELIAL-CELLS; SIGNAL-TRANSDUCTION; CARDIAC DEVELOPMENT; HEART DEVELOPMENT; II RECEPTOR;

D O I：

10.1016/j.yexcr.2013.02.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood vessels are composed of endothelial cells, mural cells (smooth muscle cells and pericytes) and their shared basement membrane. During embryonic development a multitude of signaling components orchestrate the formation of new vessels. The process is highly dependent on correct dosage, spacing and timing of these signaling molecules. As vessels mature some cascades remain active, albeit at very low levels, and may be reactivated upon demand. Members of the Transforming growth factor beta (TGF-beta) protein family are strongly engaged in developmental angiogenesis but are also regulators of vascular integrity in the adult. In humans various genetic alterations within this protein family cause vascular disorders, involving disintegration of vascular integrity. Here we summarize and discuss recent data gathered from conditional and endothelial cell specific genetic loss-of-function of members of the TGF-beta family in the mouse. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：1264 / 1270

页数：7

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