Substrate Specificity of Na+,Cl-(HCO3 -)-ATPase

被引：0
|
作者：
Yurkiv, V. A. [1 ]
Melikhov, V. I. [1 ]
Shubin, V. S. [1 ]
机构：
[1] Russian Acad Sci, Res Inst Gen Pathol & Pathol Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 05期
关键词：
secretory process; small intestine; Na+; Cl-(HCO3-)-ATPase; CFTR protein; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR; TRANSPORT; INTESTINE; BINDING; NHE3;
D O I：
10.1007/s10517-016-3477-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied substrate specificity of Na+,Cl-(HCO3 (-))-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na+,Cl-(HCO3 (-))-ATPase is a highly specific enzyme for ATP.
引用
收藏
页码：651 / 653
页数：3
相关论文
共 50 条
  • [41] Insulin stimulates the Na+,K+-ATPase and the Na+/K+/Cl- cotransporter of human fibroblasts
    Longo, N
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1996, 1281 (01): : 38 - 44
  • [42] PHYSIOLOGY OF NA+ AND CL- METABOLISM
    GREGER, R
    NIEREN-UND HOCHDRUCKKRANKHEITEN, 1994, 23 : S5 - S9
  • [43] Na+,HCO3− cotransporter NBCn1 accelerates breast carcinogenesis
    Ebbe Boedtkjer
    Cancer and Metastasis Reviews, 2019, 38 : 165 - 178
  • [44] Molecular and functional evidence for a Na+–HCO3−-cotransporter in sheep ruminal epithelium
    K. Huhn
    F. Müller
    K. U. Honscha
    H. Pfannkuche
    G. Gäbel
    Journal of Comparative Physiology B, 2003, 173 : 277 - 284
  • [45] Biochemical properties of the sensitivity to GABAAergic ligands, Cl-/HCO3 --ATPase isolated from fish (Cyprinus carpio) olfactory mucosa and brain
    Menzikov, Sergey
    FISH PHYSIOLOGY AND BIOCHEMISTRY, 2018, 44 (02) : 583 - 597
  • [46] Migration of transformed MDCK cells depends on Na+/H+ and on Cl-/HCO3- exchange.
    Seeger, P
    Reinhardt, J
    Schwab, A
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1997, 433 (06): : P593 - P593
  • [47] Solubilities at 25°C in the Na+,(C2H5)2NH2+∥HCO3,Cl-:H2O system
    Mazunin, SA
    Zubarev, MP
    Panasenko, VA
    RUSSIAN JOURNAL OF INORGANIC CHEMISTRY, 2000, 45 (09) : 1441 - 1450
  • [48] PHENOMENOLOGIC DESCRIPTION OF NA+, CL- AND HCO-/3 ABSORPTION FROM PROXIMAL TUBULES OF RAT-KIDNEY
    FROMTER, E
    RUMRICH, G
    ULLRICH, KJ
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1973, 343 (03): : 189 - 220
  • [49] EVIDENCE FOR THE OPERATION OF COUPLED NA+/H+ AND CL-/HCO3-ANTIPORTS IN ISOLATED RAT HEPATOCYTES
    BEAR, CE
    STRASBERG, SM
    GASTROENTEROLOGY, 1984, 86 (05) : 1311 - 1311
  • [50] Expression of the Na+/H+ and Cl-/HCO3- exchanger isoforms in proximal and distal human airways
    Dudeja, PK
    Hafez, N
    Tyagi, S
    Gailey, CA
    Toofanfard, M
    Alrefai, WA
    Nazir, TM
    Ramaswamy, K
    Al-Bazzaz, FJ
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 276 (06) : L971 - L978
12345