Substrate Specificity of Na+,Cl-(HCO3 -)-ATPase

被引：0
|
作者：
Yurkiv, V. A. [1 ]
Melikhov, V. I. [1 ]
Shubin, V. S. [1 ]
机构：
[1] Russian Acad Sci, Res Inst Gen Pathol & Pathol Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 05期
关键词：
secretory process; small intestine; Na+; Cl-(HCO3-)-ATPase; CFTR protein; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR; TRANSPORT; INTESTINE; BINDING; NHE3;
D O I：
10.1007/s10517-016-3477-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied substrate specificity of Na+,Cl-(HCO3 (-))-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na+,Cl-(HCO3 (-))-ATPase is a highly specific enzyme for ATP.
引用
收藏
页码：651 / 653
页数：3
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