Sonogashira Reaction: Synthesis of Novel Derivatives of 3-Aryl-Substituted 6-Chloroimidazo[2, 1-a]phthalazines Catalyzed by Pd-Cu in Water

被引：4

作者：

Bakherad, Mohammad ^{[1
]}

Karami, Saeed ^{[1
]}

Keivanloo, Ali ^{[1
]}

机构：

[1] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 09期

关键词：

Anti-bacterial activity; Aryl bromides; Aryl iodides; Imidazolophthalazine; Sonogashira reaction; PHTHALAZINE DERIVATIVES; TERMINAL ACETYLENES; COUPLING REACTIONS; POTENT INHIBITORS; INTERNAL ALKYNES; HALIDES; ANNULATION; CHEMISTRY; ARYL; IMIDAZO<2,1-A>PHTHALAZINES;

D O I：

10.1002/slct.201702757

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of 1-chloro-4-propargylaminophthalazine with various aryl halides catalyzed by Pd-Cu in the presence of potassium carbonate, as the base, in water leads to the one-pot formation of new derivatives of 3-aryl-substituted-6-chloroimidazo-[2,1-a]phthalazines in moderate-to-good yields. Their structures are confirmed by IR and NMR spectra as well as elemental analyses. All the compounds prepared are screened invitro for their anti-bacterial activities. The preliminary results indicate that some target compounds exhibit promising anti-bacterial potency.

引用

页码：2435 / 2440

页数：6

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