MicroRNAs in Cutaneous T-Cell Lymphoma: The Future of Therapy

被引：14

作者：

Kohnken, Rebecca ^{[1
,2
]}

Mishra, Anjali ^{[2
,3
,4
]}

机构：

[1] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Internal Med, Div Dermatol, Columbus, OH 43210 USA

[4] Thomas Jefferson Univ, Dept Canc Biol, Dept Med Oncol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2019年 / 139卷 / 03期

基金：

美国国家卫生研究院;

关键词：

MYCOSIS-FUNGOIDES; DOWN-REGULATION; TUMOR-SUPPRESSOR; DNA METHYLATION; EXPRESSION; CANCER; MIRNA; ACTIVATION; RESISTANCE; MIR-155;

D O I：

10.1016/j.jid.2018.10.035

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

MicroRNAs (miRs) are small, noncoding RNAs with numerous cellular functions. With advancing knowledge of the many functions of miRs in cancer pathogenesis, there is emerging interest in miRs as therapeutic targets in cancers. One disease that poses an intriguing model for miR therapy is cutaneous T-cell lymphoma, a rare disease featuring malignant CD4 thorn T cells that proliferate in the skin. The hallmark of cutaneous T-cell lymphoma progression is epigenetic dysregulation, with aberrant miR levels being a common feature. This review aims to summarize the rapidly emerging advances in the development of miR-based therapies in cancers, with a special emphasis on CTCL.

引用

页码：528 / 534

页数：7

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