Ginger extract increases muscle mitochondrial biogenesis and serum HDL-cholesterol level in high-fat diet-fed rats

被引：35

作者：

Oh, Soojung ^{[1
]}

Lee, Mak-Soon ^{[1
]}

Jung, Sunyoon ^{[1
]}

Kim, Seunghae ^{[1
]}

Park, Hyeyoung ^{[1
]}

Park, Seonyoung ^{[1
]}

Kim, Seog-Young ^{[1
]}

Kim, Chong-Tai ^{[2
]}

Jo, Young-Hee ^{[2
]}

Kim, In-Hwan ^{[3
]}

Kim, Yangha ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea

[2] Korea Food Res Inst, Res Grp Bioproc Engn, Seongnam 13539, Gyeonggi, South Korea

[3] Korea Univ, Dept Food & Nutr, Seoul 02841, South Korea

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 29卷

基金：

新加坡国家研究基金会;

关键词：

Ginger; Muscle mitochondrial biogenesis; HDL cholesterol; Metabolic disorder; DENSITY-LIPOPROTEIN CHOLESTEROL; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; ZINGIBER-OFFICINALE; ACID-METABOLISM; OXIDATIVE CAPACITY; INDUCED OBESITY; TRANSCRIPTION; MANAGEMENT; PATHWAYS;

D O I：

10.1016/j.jff.2016.12.023

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Mitochondrial dysfunction and dyslipidemia are associated with obesity-linked metabolic disorders. The aim of this study was to investigate the effects of ginger extract on muscle mitochondrial biogenesis and high-density lipoprotein-cholesterol (HDL-C) metabolism in high-fat diet-fed rats. Supplementation with ginger extract reduced final body weight and epididymal adipose tissue mass without affecting energy intake (p < 0.05). Ginger extract increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as key genes expression related to mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha), nuclear respiratory factor-1 (NRF-1) and transcription factor A (Tfam) in skeletal muscle (p < 0.05). In addition, ginger extract elevated serum HDL-C along with up regulating ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-1 (ApoA-1) and lecithin-cholesterol acyltransferase (LCAT) mRNA in liver (p < 0.05). These results suggest that ginger extract may have a beneficial effect against obesity-related metabolic disorders with elevating muscle mitochondrial biogenesis and serum HDL-C level. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：193 / 200

页数：8

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