Saw palmetto ethanol extract inhibits adipocyte differentiation

被引：2

作者：

Villaverde, Nicole ^{[1
]}

Galvis, Adriana ^{[1
]}

Marcano, Adriana ^{[1
]}

Priestap, Horacio A. ^{[1
]}

Bennett, Bradley C. ^{[1
]}

Barbieri, M. Alejandro ^{[1
,2
]}

机构：

[1] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA

[2] Fairchild Trop Bot Garden, Miami, FL 33156 USA

来源：

JOURNAL OF NATURAL MEDICINES | 2013年 / 67卷 / 03期

关键词：

Saw palmetto; Serenoa repens (Bartr.); Small; Arecaceae; Differentiation; Transcriptional factors; Signaling pathways; Adipocyte differentiation; STANDARD REFERENCE MATERIALS; 3T3-L1; PREADIPOCYTES; GENE-EXPRESSION; ADIPOSE-TISSUE; SERENOA-REPENS; FATTY-ACIDS; GLUCOSE-TRANSPORTER-4; TRANSLOCATION; STEROID; 5-ALPHA-REDUCTASE; SUBCUTANEOUS FAT; CELL-GROWTH;

D O I：

10.1007/s11418-012-0723-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The fruits of saw palmetto have been used for the treatment of a variety of urinary and reproductive system problems. In this study we investigated whether the fruit extracts affect in vitro adipogenesis. Saw palmetto ethanol extract inhibited the lipid droplet accumulation by induction media in a dose-dependent manner, and it also attenuated the protein expressions of C-EBP alpha and PPAR gamma. Phosphorylation of Erk1/2 and Akt1 were also decreased by saw palmetto ethanol extract. This report suggests that saw palmetto extracts selectively affect the adipocyte differentiation through the modulation of several key factors that play a critical role during adipogenesis.

引用

页码：619 / 625

页数：7

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