Synthesis and photophysicochemical studies of poly(ethylene glycol) conjugated symmetrical and asymmetrical zinc phthalocyanines

被引：20
作者：
Dincer, Hatice [1 ]
Mert, Humeyra [2 ]
Caliskan, Emel [2 ]
Atmaca, Goknur Yasa [3 ]
Erdogmus, Ali [3 ]
机构：
[1] Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkey
[2] Hitit Univ, Fac Engn, Dept Chem Engn, TR-19030 Corum, Turkey
[3] Yildiz Tech Univ, Fac Arts & Sci, Dept Chem, TR-34210 Istanbul, Turkey
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2015年 / 1102卷
关键词：
Symmetrical zinc phthalocyanine; Asymmetrical zinc phthalocyanine; Click; Star polymer; Photodynamic therapy; HALOGENATED SILICON(IV) PHTHALOCYANINES; WATER-SOLUBLE PHTHALOCYANINES; PHOTODYNAMIC THERAPY; STAR POLYMERS; PHOTOSENSITIZER; PORPHYRINS; PEGYLATION; CHLORO; CHAINS;
D O I：
10.1016/j.molstruc.2015.08.067
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Synthesis and characterization of poly(ethylene glycol) conjugated symmetrical and asymmetrical zinc phthalocyanines (ZnPcs) is described. Copper (I) catalyzed azide-alkyne cycloaddition (CuAAC) click reaction between azide functional methoxypoly(ethylene glycol) (mPEG-N-3) and tetra terminal alkynyl substituted ZnPc yields star polymer with ZnPc core. Furthermore, CuAAC click reaction between asymmetrically terminal alkynyl substituted zinc phthalocyanine (aZnPc) and mPEG-N-3 yields aZnPc end functionalized PEG. Spectral, photophysical (fluorescence quantum yield), photochemical (singlet oxygen (Phi(Delta)), and photodegradation quantum yield (Phi(d)) properties of the symmetrically, and asymmetrically PEGylated ZnPcs are investigated to be used as sensitizers in photodynamic therapy (PDT). The quantum yield values of fluorescence (Phi(F)) and singlet oxygen generation (Phi(Delta)) for water soluble symmetrically PEGylated ZnPc in aqueous solution are calculated as 0.01 and 0.14 respectively, suggesting its potential as photosensitizer in PDT treatment. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：190 / 196
页数：7
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