Human olfactory receptor responses to odorants

被引：109

作者：

Mainland, Joel D. ^{[1
,2
,3
]}

Li, Yun R. ^{[2
]}

Zhou, Ting ^{[2
]}

Liu, Wen Ling L. ^{[2
]}

Matsunami, Hiroaki ^{[2
,4
,5
]}

机构：

[1] Monell Chem Senses Ctr, 3500 Market St, Philadelphia, PA 19104 USA

[2] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[3] Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA

[4] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Duke Inst Brain Sci, Durham, NC 27710 USA

来源：

SCIENTIFIC DATA | 2015年 / 2卷

关键词：

FUNCTIONAL EXPRESSION; GENETIC-VARIATION; SENSITIVITY; IDENTIFICATION; SPECIFICITY; ACTIVATION; ODORS; CELLS;

D O I：

10.1038/sdata.2015.2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

引用

页数：9

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