Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma

被引：3
作者：
Gorphe, Philippe [1 ]
Chekkoury Idrissi, Younes [1 ]
Tao, Yungan [2 ]
Moya-Plana, Antoine [1 ]
Casiraghi, Odile [3 ]
Janot, Francois [1 ]
Blanchard, Pierre [2 ]
Mirghani, Haitham [1 ]
Temam, Stephane [1 ]
机构：
[1] Univ Paris Saclay, Inst Gustave Roussy, Dept Head & Neck Oncol, Villejuif, France
[2] Univ Paris Saclay, Inst Gustave Roussy, Dept Radiotherapy, Villejuif, France
[3] Univ Paris Saclay, Inst Gustave Roussy, Dept Pathol, Villejuif, France
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 04期
关键词：
human papillomavirus; N3; oropharyngeal neoplasms; p16; immunohistochemistry; smoking history; POSITIVE HEAD; CANCER; OUTCOMES; CHEMORADIOTHERAPY; RISK; RADIOTHERAPY; INTEGRATION; PROGNOSIS; RADIATION; SURVIVAL;
D O I：
10.1002/hed.25523
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P = .02 and P = .03, respectively) and PFS (P = .02 and P = .02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.
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收藏
页码：1039 / 1045
页数：7
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