A sustainable approach to the Ugi reaction in deep eutectic solvent

被引：39

作者：

Azizi, Najmedin ^{[1
]}

Dezfooli, Sahar ^{[2
]}

Hashemi, Mohammad Mahmoodi ^{[3
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran

[2] Islamic Azad Univ, Young Researchers & Elites Club, Sci & Res Branch, Tehran, Iran

[3] Sharif Univ Technol, Tehran, Iran

来源：

COMPTES RENDUS CHIMIE | 2013年 / 16卷 / 12期

基金：

美国国家科学基金会;

关键词：

Ugi reaction; Green chemistry; Deep eutectic solvent; Choline chloride; Urea; HIGHLY EFFICIENT SYNTHESIS; MULTICOMPONENT REACTIONS; IONIC LIQUIDS; ISOCYANIDES; DESIGN; ACID;

D O I：

10.1016/j.crci.2013.05.013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Ugi reaction goes fast with high yields in a recyclable and biodegradable low-melting mixture of choline chloride and urea (DES) as a novel and efficient reaction medium. The DES is applicable to a wide range of aldehydes, amines, isocyanides, and acids in good to excellent isolated yields (60-92%) and short reaction times (2-5 h) and can be reused four times without any loss of activity. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：1098 / 1102

页数：5

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