Effects of Stingless Bee Propolis on Experimental Asthma

被引：23

作者：

Cavalcante de Farias, Jose Hidelbland ^{[1
]}

Reis, Aramys Silva ^{[1
]}

Rodrigues Araujo, Marcio Antonio ^{[1
]}

Abigail Mendes Araujo, Maria Jose ^{[1
]}

Martins Assuncao, Anne Karine ^{[1
]}

de Farias, Jardel Cavalcante ^{[1
]}

Silva Fialho, Eder Magalhaes ^{[1
]}

Silva, Lucilene Amorim ^{[1
]}

Costa, Graciomar Conceicao ^{[1
]}

Meireles Guerra, Rosane Nassar ^{[1
]}

Sousa Ribeiro, Maria Nilce ^{[2
]}

Fernandes do Nascimento, Flavia Raquel ^{[1
]}

机构：

[1] Fed Univ Maranhao UFMA, Biol & Hlth Sci Ctr, Dept Pathol, BR-65085580 Sao Luis, MA, Brazil

[2] Fed Univ Maranhao UFMA, Biol & Hlth Sci Ctr, Dept Pharm, Lab Pharmacognosy, BR-65085580 Sao Luis, MA, Brazil

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷

关键词：

SCAPTOTRIGONA AFF. POSTICA; INTERFERON-GAMMA; MURINE MODEL; MICE; EXTRACT; INFLAMMATION; INHIBITION; MECHANISMS; EXPRESSION; COMPONENTS;

D O I：

10.1155/2014/951478

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously. After 14 days, they were intranasally challenged with OVA. Groups P50 and P200 received PHE by gavage at doses of 50 and 200mg/kg, respectively. The DEXA group was treated with intraperitoneal injection of dexamethasone. The OVA group received only water. The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA. The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL). Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells. In addition, the concentration of interferon-gamma (IFN-gamma) in the serum was decreased. These results were similar to those obtained with dexamethasone. Treatment with S. aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation.

引用

页数：8

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