Prenatal exposure to magnetic field increases dopamine levels in the striatum of offspring

被引：12
作者：
Lee, BC
Bing, GY
Jhoo, WK
Yoon, JM
Kang, KS
Shin, EJ
Kim, WK
Ko, KH
Kim, HC [1 ]
机构：
[1] Kangweon Natl Univ, Coll Pharm, Neurotoxicol Program, Korea Inst Drug Abuse, Chunchon 200701, South Korea
[2] Ewha Univ Med Sch, Ewha Inst Neurosci, Dept Pharmacol, Seoul, South Korea
[3] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[4] Univ Kentucky, Med Ctr, Lexington, KY USA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2001年 / 28卷 / 11期
关键词：
dopamine; magnetic field; perinatal effect; striatum;
D O I：
10.1046/j.1440-1681.2001.03538.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The putative effects of prenatal exposure to magnetic field (MF) have recently received much interest. In the present study, mice were exposed to a MF of 50 mT during gestation (0-19 days). 2. After the exposure was terminated, mothers and offspring were returned to normal laboratory conditions. We then determined changes in striatal levels of dopamine (DA) and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the offspring. 3. Our results indicate that prenatal exposure to MF increases levels of DA and DOPAC in the striatum at 4, 8 and 12 weeks postnatally.
引用
收藏
页码：884 / 886
页数：3
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