Controlling nanostructure and lattice parameter of the inverse bicontinuous cubic phases in functionalised phytantriol dispersions

被引：28

作者：

Fraser, Scott J. ^{[1
,2
]}

Mulet, Xavier ^{[2
]}

Hawley, Adrian ^{[3
]}

Separovic, Frances ^{[1
]}

Polyzos, Anastasios ^{[2
]}

机构：

[1] Univ Melbourne, Inst Bio21, Sch Chem, Melbourne, Vic 3010, Australia

[2] CSIRO Mat Sci & Engn, Clayton, Vic 3169, Australia

[3] Australian Synchrotron, Clayton, Vic 3169, Australia

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2013年 / 408卷

关键词：

Cubosomes; Hexosomes; Lyotropic liquid crystals; Monoolein; Phytantriol; Inverse bicontinuous cubic phase; X-RAY-DIFFRACTION; DRUG-DELIVERY; WATER SYSTEMS; CUBOSOMES; NANOPARTICLES; SCATTERING; MICELLES; VEHICLES; BEHAVIOR; POLYMER;

D O I：

10.1016/j.jcis.2013.07.002

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The preparation and phase behavior of dispersed liquid crystalline particles comprised of phytantriol and various functionalised lipids are reported. These inverse bicontinuous cubic phase colloidal dispersions have been sterically stabilized with a triblock copolymer, Pluronic F127. The influence of added negatively charged amphiphiles oleic acid and sodium dodecylsulfate, the positively charged hexadecyltrimethylammonium bromide, and monoolein a neutral amphiphile, on phase behavior and cubic phase structure was examined by synchrotron small angle X-ray scattering (SAXS). Functionality was also introduced through ligand specific lipids monosialoganglioside-G(M1) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000]. SAXS measurements showed that all of the additives affected the long-range order of the inverse cubic phase observed through either phase behavior changes or alteration in lattice parameter. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.

引用

页码：117 / 124

页数：8

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