Kinetic Resolution, Dynamic Kinetic Resolution and Asymmetric Desymmetrization by N-Heterocyclic Carbene Catalysis

被引：41

作者：

De Risi, Carmela ^{[1
]}

Bortolini, Olga ^{[1
]}

Di Carmine, Graziano ^{[1
]}

Ragno, Daniele ^{[1
]}

Massi, Alessandro ^{[1
]}

机构：

[1] Univ Ferrara, Dipartimento Sci Chim & Farmaceut, Via L Borsari 46, I-44121 Ferrara, Italy

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 09期

关键词：

N-heterocyclic carbenes; kinetic resolution; dynamic kinetic resolution; asymmetric desymmetrization; organocatalysis; asymmetric synthesis; INTRAMOLECULAR STETTER REACTION; ENANTIOSELECTIVE SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; CHEMOSELECTIVE ACYLATION; NATURAL-PRODUCTS; ALCOHOLS; ESTERS; ACTIVATION; ACCESS; CYCLOHEXADIENONES;

D O I：

10.1055/s-0037-1612305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Heterocyclic carbenes (NHCs) are now well-established organocatalysts for a large number of asymmetric and non-asymmetric transformations. In the last 15 years, there has been significant interest in using NHCs in kinetic resolution (KR), dynamic kinetic resolution (DKR) and asymmetric desymmetrization reactions for the stereoselective synthesis of enantioenriched compounds, with diverse substrates and activation modes being adopted to this end. This short review brings into focus the progress made on NHC-catalyzed KR, DKR, and asymmetric desymmetrization from 2004 until December 2018. The literature discussed in this article is classified on the basis of the type of reaction involving the NHC catalyst. 1 Introduction 2 Acylation Strategies 2.1 O-Acylation 2.2 N-Acylation 2.3 C-Acylation 3 Aldol-Acylation Processes 4 Benzoin Reactions 5 Stetter Reactions 6 Miscellaneous Approaches 7 Conclusion

引用

页码：1871 / 1891

页数：21

共 138 条

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