Role of microRNA-155 in rheumatoid arthritis

被引：63

作者：

Su, Lin-Chong ^{[1
,2
]}

Huang, An-Fang ^{[3
]}

Jia, Hong ^{[4
]}

Liu, Yi ^{[1
]}

Xu, Wang-Dong ^{[4
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Rheumatol & Immunol, 37 Guoxue Xiang, Chengdu 610041, Sichuan, Peoples R China

[2] Hubei Inst Nationalities, Affiliated Minda Hosp, Dept Rheumatol & Immunol, Enshi, Hubei, Peoples R China

[3] Southwest Med Univ, Affiliated Hosp, Dept Rheumatol & Immunol, Luzhou, Sichuan, Peoples R China

[4] Southwest Med Univ, Sch Publ Hlth, 1 Xianglin Rd, Luzhou 646000, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2017年 / 20卷 / 11期

基金：

中国国家自然科学基金;

关键词：

autoimmunity; microRNA-155; rheumatoid arthritis; TH17; CELL-DIFFERENTIATION; EXPRESSION; MIR-155; COMPLEX; TISSUE;

D O I：

10.1111/1756-185X.13202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are a recently discovered class of post-transcriptional regulators that induce target messenger RNA degradation or translation inhibition. miRNA-155 (miR-155) is an important regulator of immune cells both in humans and mice, by which these cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recent findings showed that expression of miR-155 was elevated in RA patients and arthritis models. Moreover, miR-155 overexpression or knockdown performed significantly in the development of arthritis. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related autoimmune arthritis. Hopefully the information obtained will benefit the development of novel therapeutic strategies.

引用

页码：1631 / 1637

页数：7

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