Epigenetics advancing personalized nanomedicine in cancer therapy

被引：29
作者：
Liu, Shujun [1 ]
机构：
[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2012年 / 64卷 / 13期
关键词：
Epigenetics; Biomarkers; Targeted therapy; Nanotechnology; Nanoparticles; Drug delivery; Personalized medicine; Nanomedicine; Personalized nanomedicine; ACUTE MYELOID-LEUKEMIA; DNA METHYLTRANSFERASES DNMT1; BREAST-CANCER; LUNG-CANCER; PROMOTER HYPERMETHYLATION; COLORECTAL-CANCER; MULTIPLE GENES; CPG-ISLAND; HISTONE MODIFICATIONS; METHYLATION;
D O I：
10.1016/j.addr.2012.08.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Personalized medicine aims to deliver the right drug to a right patient at the right time. It offers unique opportunities to integrate new technologies and concepts to disease prognosis, diagnosis and therapeutics. While selective personalized therapies are conceptually impressive, the majority of cancer therapies have dismal outcome. Such therapeutic failure could result from no response, drug resistance, disease relapse or severe side effect from improper drug delivery. Nanomedicine, the application of nanotechnology in medicine, has a potential to advance the identification of diagnostic and prognostic biomarkers and the delivery of right drug to disease sites. Epigenetic aberrations dynamically contribute to cancer pathogenesis. Given the individualized traits of epigenetic biomarkers, epigenetic considerations would significantly refine personalized nanomedicine. This review aims to dissect the interface of personalized medicine with nanomedicine and epigenetics. I will outline the progress and highlight challenges and areas that can be further explored perfecting the personalized health care. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：1532 / 1543
页数：12
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