Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately

被引：47

作者：

Yoshida, Tsukasa ^{[1
,2
]}

Hijioka, Susumu ^{[1
,3
]}

Hosoda, Waki ^{[4
,5
]}

Ueno, Makoto ^{[6
]}

Furukawa, Masayuki ^{[7
]}

Kobayashi, Noritoshi ^{[8
]}

Ikeda, Masafumi ^{[9
]}

Ito, Tetsuhide ^{[10
]}

Kodama, Yuzo ^{[11
]}

Morizane, Chigusa ^{[3
]}

Notohara, Kenji ^{[12
]}

Taguchi, Hiroki ^{[13
]}

Kitano, Masayuki ^{[14
]}

Yane, Kei ^{[15
]}

Tsuchiya, Yoshiaki ^{[16
]}

Komoto, Izumi ^{[17
]}

Tanaka, Hiroki ^{[18
]}

Tsuji, Akihito ^{[19
]}

Hashigo, Syunpei ^{[20
]}

Mine, Tetsuya ^{[21
]}

Kanno, Atsushi ^{[22
]}

Murohisa, Go ^{[23
]}

Miyabe, Katsuyuki ^{[24
]}

Takagi, Tadayuki ^{[25
]}

Matayoshi, Nobutaka ^{[26
]}

Sakaguchi, Masafumi ^{[27
]}

Ishii, Hiroshi ^{[28
,29
]}

Kojima, Yasushi ^{[30
]}

Matsuo, Keitaro ^{[31
]}

Yoshitomi, Hideyuki ^{[32
]}

Nakamori, Shoji ^{[33
]}

Yanagimoto, Hiroaki ^{[34
]}

Yatabe, Yasushi ^{[4
]}

Furuse, Junji ^{[35
]}

Mizuno, Nobumasa ^{[1
]}

机构：

[1] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi, Japan

[2] Kizawa Mem Hosp, Dept Gastroenterol, Minokamo, Japan

[3] Natl Canc Ctr, Dept Hepatobiliary & Pancreat Oncol, Tokyo, Japan

[4] Aichi Canc Ctr Hosp, Dept Pathol & Mol Diagnost, Nagoya, Aichi, Japan

[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[6] Kanagawa Canc Ctr, Div Hepatobiliary & Pancreat Med Oncol, Yokohama, Kanagawa, Japan

[7] Kyushu Natl Canc Ctr, Dept Hepatobiliary Pancreatol, Fukuoka, Fukuoka, Japan

[8] Yokohama City Univ Med, Dept Oncol, Yokohama, Kanagawa, Japan

[9] Natl Canc Ctr Hosp East, Dept Hepatobiliary & Pancreat Oncol, Kashiwa, Chiba, Japan

[10] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka, Fukuoka, Japan

[11] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[12] Kurashiki Cent Hosp, Dept Anat Pathol, Kurashiki, Okayama, Japan

[13] Kagoshima Univ, Dept Digest & Lifestyle Dis, Grad Sch Med & Dent Sci, Kagoshima, Japan

[14] Kinki Univ, Dept Gastroenterol & Hepatol, Fac Med, Sayama, Osaka, Japan

[15] Teine Keijinkai Hosp, Ctr Gastroenterol, Sapporo, Hokkaido, Japan

[16] Niigata Canc Ctr Hosp, Dept Digest Surg, Niigata, Japan

[17] Kansai Elect Power Hosp, Dept Surg, Osaka, Japan

[18] Suzuka Gen Hosp, Dept Gastroenterol, Suzuka, Japan

[19] Kobe City Med Ctr Gen Hosp, Dept Med Oncol, Kobe, Hyogo, Japan

[20] Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol & Hepatol, Kumamoto, Japan

[21] Tokai Univ, Dept Gastroenterol, Sch Med, Isehara, Kanagawa, Japan

[22] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Sendai, Miyagi, Japan

[23] Seirei Hamamatsu Gen Hosp, Dept Gastroenterol, Hamamatsu, Shizuoka, Japan

[24] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Nagoya, Aichi, Japan

[25] Fukushima Med Univ, Sch Med, Dept Gastroenterol, Fukushima, Japan

[26] Univ Occupat & Environm Hlth, Sch Med, Dept Surg, Kitakyushu, Fukuoka, Japan

[27] Saiseikai Kumamoto Hosp, Dept Gastroenterol, Kumamoto, Japan

[28] Shikoku Canc Ctr, Dept Gastroenterol, Matsuyama, Ehime, Japan

[29] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol, Tokyo, Japan

[30] Natl Ctr Global Hlth & Med, Dept Gastroenterol, Ctr Hosp, Tokyo, Japan

[31] Aichi Canc Ctr, Div Mol & Clin Epidemiol, Res Inst, Nagoya, Aichi, Japan

[32] Chiba Univ, Grad Sch Med, Dept Gen Surg, Chiba, Japan

[33] Natl Hosp Org Osaka Natl Hosp, Dept Hepatobiliary Pancreat Surg, Osaka, Japan

[34] Kansai Med Univ Hosp, Dept Surg, Maikata, Japan

[35] Kyorin Univ, Fac Med, Dept Med Oncol, Mitaka, Tokyo, Japan

来源：

ANNALS OF SURGICAL ONCOLOGY | 2019年 / 26卷 / 05期

基金：

日本学术振兴会;

关键词：

HIGH-GRADE; CONSENSUS GUIDELINES; SURGICAL-MANAGEMENT; PROGNOSTIC-FACTORS; LIVER METASTASES; SMALL-CELL; RESECTION; SURVIVAL;

D O I：

10.1245/s10434-019-07252-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. The role of surgery in pancreatic neuroendocrine neoplasm grade3 (pNEN-G3) treatment remains unclear. We aimed to clarify the role of surgery for pNEN-G3, which has recently been reclassified as pancreatic neuroendocrine tumor-G3 (pNET-G3) and pancreatic neuroendocrine carcinoma-G3 (pNEC-G3), with and without metastases, respectively. Methods. We analyzed a subgroup of patients from the Japanese pancreatic NEC study, a Japanese multicenter case-series study of pNEN-G3. Pathologists subclassified 67 patients as having pNET-G3 or pNEC-G3 based on morphological features. We compared the overall survival (OS) rates among patients who were grouped according to whether they had undergone tumor-targeted surgery for tumors without (SwoM) or with (SwM) metastases, or non-surgical procedures (NS). Results. Data from 21 patients with pNET-G3 (SwoM, n=6; SwM, n=5; NS, n=10) and 46 patients with pNEC-G3 (SwoM, n=8; SwM, n=5; NS, n=33) were analyzed. OS of patients with pNET-G3 was significantly longer after SwoM and SwM than with NS (p=0.018 and p=0.022). In contrast, OS did not significantly differ between either SwoM or SwM and NS (p=0.093 and p=0.489) among patients with pNEC-G3. Conclusion. The role of surgery should be considered separately for pNET-G3 and pNEC-G3. Although SwoM and SwM can be considered for pNET-G3, caution is advised before considering SwM and SwoM for pNEC-G3.

引用

页码：1385 / 1393

页数：9

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