Proteomics of pediatric heart failure: from traditional biomarkers to new discovery strategies

被引：3
|
作者：
Xu, Mingguo [1 ,2 ]
Ramirez-Correa, Genaro A. [1 ]
Murphy, Anne M. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Cardiol, Baltimore, MD 21205 USA
[2] Shen Zhen Childrens Hosp, Dept Internal Cardiol, Shenzhen, Peoples R China
来源：
CARDIOLOGY IN THE YOUNG | 2015年 / 25卷
关键词：
Biomarker; heart failure; proteomics; post-translational modification; NATRIURETIC PEPTIDE LEVELS; CARDIAC TROPONIN-I; HYPERTROPHIC CARDIOMYOPATHY; PLASMA NOREPINEPHRINE; YOUNG-CHILDREN; BREAST-CANCER; DISEASE; SERUM; HEALTHY; MARKER;
D O I：
10.1017/S1047951115000839
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.
引用
收藏
页码：51 / 57
页数：7
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