Sinulasulfoxide and sinulasulfone, sulfur-containing alkaloids from the Indonesian soft coral Sinularia sp.

被引：13

作者：

Putra, Masteria Yunovilsa ^{[1
,2
]}

Ianaro, Angela ^{[3
]}

Panza, Elisabetta ^{[3
]}

Bavestrello, Giorgio ^{[4
]}

Cerrano, Carlo ^{[2
]}

Fattorusso, Ernesto ^{[1
]}

Taglialatela-Scafati, Orazio ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Politecn Marche, Dipartimento Sci Mare, I-60131 Ancona, Italy

[3] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[4] Univ Genoa, Dipartimento Studio Terr & Sue Risorse, I-16132 Genoa, Italy

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 30期

关键词：

Sinularia; Soft coral; Sulfur-containing compounds; Alkaloids; iNOS inhibition; INHIBITOR; METABOLITES; ACID;

D O I：

10.1016/j.tetlet.2012.05.095

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two new alkaloids, named sinulasulfoxide (1) and sinulasulfone (2), characterized by an amide linkage between a phytanic acid moiety and an uncommon sulfur-containing unit. Their complete stereostructures were elucidated by interpretation of MS and NMR data along with CD analysis and chemical modifications. Sinulasulfoxide (1) proved to moderately inhibit LPS-induced NO release. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3937 / 3939

页数：3

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