USP10 regulates Musashi-2 stability via deubiquitination and promotes tumour proliferation in colon cancer

被引：30
|
作者：
Ouyang, Si-wen [1 ]
Liu, Ting-ting [2 ]
Liu, Xi-sheng [1 ]
Zhu, Fu-xiang [3 ]
Zhu, Fang-ming [4 ]
Liu, Xue-ni [1 ]
Peng, Zhi-hai [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gen Surg, Sch Med, 85 Wujin Rd, Shanghai 200080, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Rheumatol & Immunol, Sch Med, Shanghai, Peoples R China
[3] Univ Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai Inst Biol Sci, Unit Mol Immunol, Shanghai, Peoples R China
[4] Shanghai Univ, Shanghai Key Lab Bioenergy Crops, Shanghai, Peoples R China
来源：
FEBS LETTERS | 2019年 / 593卷 / 04期
基金：
中国国家自然科学基金;
关键词：
colon cancer; deubiquitination; MSI2; proliferation; USP10; CELL-FATE; P53; STATISTICS; ACTIVATION;
D O I：
10.1002/1873-3468.13323
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have demonstrated that ubiquitin-specific protease 10 (USP10) plays a catalytic role in tumour suppression mainly by deubiquitinating its target proteins to enhance their stabilities. However, we found that USP10 could interact with and regulate the expression of oncogenic factor Musashi-2 (MSI2). We investigated whether USP10 positively regulates the expression of MSI2 by deubiquitination and confirmed the type of polyubiquitin chain that is linked to MSI2. We also explored the role of USP10 in regulating the proliferation of colon cancer through different experiments. This study provides a completely new perspective in understanding the role of USP10 in deubiquitination. In the future, USP10 may serve as a target for colon cancer treatment.
引用
收藏
页码：406 / 413
页数：8
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